Nuclear Mechanics and Genome Regulation

Volume 98
Herausgegeben:Shivashankar, G.V.

• Gebundenes Buch

Produktbeschreibung

In recent years new discoveries have made this an exciting and important field of research. This exhaustive volume presents comprehensive chapters and detailed background information for researchers working with in the field of nuclear mechanics and genome regulation.

Produktdetails

• Methods in Cell Biology Volume 98
• Verlag: Academic Press
• Artikelnr. des Verlages: C2009-0-01954-0
• Seitenzahl: 392
• Erscheinungstermin: 23. September 2010
• Englisch
• Abmessung: 245mm x 197mm x 23mm
• Gewicht: 874g
• ISBN-13: 9780123810090
• ISBN-10: 0123810094
• Artikelnr.: 29932940

Inhaltsangabe

Section-A: Cell Nucleus: Organization and MechanoBiology

1. Fluorescence Fluctuation Microscopy to reveal 3D-Architecture and Function in the Cell Nucleus


Thorsten Lenser^1,2, Klaus Weisshart²_, Tobias Ulbricht³, Karolin Klement³, and Peter Hemmerich


2. Studying histone modifications and their genomic functions by employing chromatin immunoprecipitation and immunoblotting


Ranveer S. Jayani, Praveena L. Ramanujam and Sanjeev Galande


3. Dynamic organization of chromatin assembly & transcription factories in living cells


Bidisha Sinha, Dipanjan Bhattacharya, Deepak Kumar Sinha, Shefali Talwar,

Shovamayee Maharana, Soumya Gupta and G. V.Shivashankar


4. Manipulation & Isolation of Single Cells & Nuclei


Swee Jin Tan, Qingsen Li and Chwee Teck Lim


5. Beyond lamins: other structural components of the nucleoskeleton


Zhixia Zhong , Katherine L. Wilson and Kris Noel Dahl


6. Altered mechanical properties of the nucleus in disease


Maria Lucia Lombardi and Jan Lammerding


7. Theoretical concepts and models of cellular mechanosensing


Rumi De, Assaf Zemel and Samuel A. Safran

Section-B: Impact of Nuclear Mechanics on Function


8. Mechanical Induction of Gene Expression in Connective Tissue Cells


Mathew Chan, Boris Hinz, Christopher A. McCulloch


9. Physical plasticity of the Nucleus and its manipulation


Irena Ivanovska, Joe Swift, Takamasa Harada, J. David Pajerowski and Dennis E. Discher


10. Prestressed Nuclear Organization in Living Cells


Aprotim Mazumder, Roopa T. , Abhishek Kumar, K.Venkatesan Iyer,

Nisha M Ramdas and G. V.Shivashankar


11. Nanotopography/mechanical induction of stem-cell differentiation


Evelyn Yim


12. Mechanical Induction in Embryonic Development and Tumour Growth: Integrative Cues through Molecular to Multi-cellular Interplay, and Evolutionary Perspectives


Maria-Elena Fernandez-Sanchez, Fanny Serman, Padra Ahmadi and Emmanuel Farge


13. Informatics based analysis of mechanosignaling in the laminopathies


Frank P.L. Lai, Radfidah A. Mutalif, Siew Cheng Phua, and Colin L. Stewart


14. Autosomal Dominant Leukodystrophy caused by lamin B1 duplications: A clinical and molecular case study of altered nuclear function and disease

Quasar Saleem Padiath and Ying-Hui Fu