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This book aims to present a Numerical Simulation of the effect of Electromagnetic radiation on the human heart tissue and to explore the effect of different frequencies In the electromagnetic spectrum( 900MHz, 1800MHz, 2400MHz) on Specific absorption rate (SAR), power density, the distribution of electromagnetic fields by Matlab program, and Finite-Difference Time-Domain (FDTD) method in 1D. We found that the heart tissue reacts more at 900 MHz compared to 1800 MHz and 2400 MHz, and the tissue absorption is higher at the lower frequency. Also, a mathematical analysis of electromagnetic radiation heating equations in a one-dimensional one-layer model has been discussed by numerically calculating the transient bioheat transfer equation and Maxwell's equations by using the finite difference method to predict the effects of thermal physics properties on the transient temperature of human heart tissue. the effects of various parameters on the temperature increase in the human heart tissue were considered such as electric field, magnetic field, thicknesses, and thermal conductivity of heart tissue. We found that the frequency most affecting the tissue is 900MHz.