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Signal processing today is performed in the vast majority of systems for ECG analysis and interpretation. The objective of ECG signal processing is manifold and comprises the improvement of measurement accuracy and reproducibility (when compared with manual measurements) and the extraction of information not readily available from the signal through visual assessment. In many situations, the ECG is recorded during ambulatory or strenuous conditions such that the signal is corrupted by different types of noise, sometimes originating from another physiological process of the body. Hence, noise reduction represents another important objective of ECG signal processing; in fact, the waveforms of interest are sometimes so heavily masked by the noise that their presence can only be revealed once appropriate signal processing has first been applied.