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Chemotherapy, while being a cornerstone in cancer treatment, often leads to a range of oral complications. These include mucositis, xerostomia, infections, altered taste and delayed wound healing, which can severely affect comfort and nutrition. Such complications compromise oral health and impact overall quality of life and treatment adherence. Pain and discomfort may interfere with eating, speaking and daily activities, adding to the psychological burden of cancer therapy. Early recognition and prompt management of oral side effects are essential to reduce morbidity. A multidisciplinary approach involving oncologists and dental professionals can greatly improve patient outcomes. Understanding these challenges highlights the importance of preventive and supportive oral care during chemotherapy.