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In recent years, there has been an increase in the number of patients seeking orthodontic treatment. Some of them are medically compromised or on medications. Orthodontists need to be aware of these conditions and how to modify their protocol of treatment accordingly They are obligated to coordinate with their patients' physicians about some orthodontic procedures and whether any modification to the treatment will be needed during the treatment Orthodontic treatment is not contraindicated in most of these conditions unless it is uncontrolled because the tissues' response to orthodontic treatment is jeopardized during the active or acute phase of an illness. This book aims to review some of the medical conditions and their relevant orthodontic considerations.