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The institute of medicine report 'To Err is Human' (Kohn & Donaldson, 2000) impacted that patient safety remains one of the most critical issues facing health care today and that nurses are the health care professionals most likely to intercept errors, prevent harm to patients, and also are at the center of patient care and therefore they are essential drivers of quality improvement. From the investigator point of view, it is critical that nursing leaders and managers, clinical leaders, and nurses across care settings engage in a lifelong pursuit of using data and information as well as research evidence to inform practice combined with experiential knowledge, analyses, and evidence. Nurses will be challenged to continuously improve care processes and encourage peers and interdisciplinary colleagues to make sure patients receive the best possible care, regardless of where they live, their race or gender, or their socioeconomic circumstances.