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The book "Studies on Pharmacognostic,Pharmacological and Antimicrobial Aspects of Solanum sisymbriifolium" presents a systematic investigation into the medicinal potential of this plant. It begins with the significance of herbal medicines and their role in primary healthcare, emphasizing the need for scientific validation. The study focuses on pharmacognostic evaluation, including macroscopic, microscopic, and physicochemical parameters to authenticate and standardize the plant material. Successive solvent extractions were performed, followed by phytochemical screening, TLC, and HPTLC fingerprinting to identify bioactive constituents such as alkaloids, flavonoids, tannins, and saponins. The crude methanol extract was tested for antimicrobial activity against bacteria and fungi, showing moderate to significant inhibition. Anti-inflammatory potential was evaluated using carrageenan-induced paw edema in rats, where CMERSS exhibited dose-dependent inhibition comparable to aspirin. The findings establish S. sisymbriifolium as a promising source of pharmacologically active compounds with potential therapeutic applications, while underscoring the importance of quality control in research.