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Teaching resources are essential tools in the teaching-learning process. In this case, games are an important and attractive methodology for students, as well as allowing teachers to diversify their lessons in order to make them more interesting, attractive and fun without losing their objective of building knowledge. To this end, a 'Population Genetics' board game was devised to address genotypic and phenotypic frequencies and the effect of evolutionary factors such as migration, mutation and natural selection. This methodology can be applied to secondary school students who already have a basic knowledge of genetics. In this way, it's possible to make it easier for the teacher to explain the content of Population Genetics and make it easier for the students to understand it in a fun and interactive way.