The relevance of genomic medicine embodies using an individual's genomics and molecular genetic information to personalize treatment and predict drug response to ensure safer and more cost-effective therapies. An African framework for implementing genomic medicine was recently developed to highlight the elements required within the African context and provide some recommendations on how African countries can work on putting them in place by building on existing infrastructure. These measures would enable resource-limited countries to implement appropriate genomics-based health-related…mehr
The relevance of genomic medicine embodies using an individual's genomics and molecular genetic information to personalize treatment and predict drug response to ensure safer and more cost-effective therapies. An African framework for implementing genomic medicine was recently developed to highlight the elements required within the African context and provide some recommendations on how African countries can work on putting them in place by building on existing infrastructure. These measures would enable resource-limited countries to implement appropriate genomics-based health-related interventions, drawing on experiences from elsewhere but adapting to the African context where necessary. In developing the framework, the existing genomic medicine activities in Africa were investigated. This book aims to describe the current status of precision medicine and discuss the clinical studies related to precision medicine that have been conducted on African populations to improve healthcarein Africa.
This book comprises three sections: infectious diseases, non-communicable diseases, and bioinformatics tools and resources. Each section is covered in several chapters, each dealing with a specific disease or group of diseases together with the necessary formalism. Based on existing literature, the collection summarizes Africa's state of the art of genomics and precision medicine activities. The book is helpful for researchers, clinicians, and policymakers; the secondary audience is students, funders, and healthcare staff.
Dr. Fouzia Radouani is the research director at Institut Pasteur du Maroc, Casablanca, Morocco. Dr Radouani is responsible for the Chlamydiae and Mycoplasma laboratory; her research interest includes all diseases associated with Chlamydiae and Mycoplasma infections (Sexually transmitted diseases, cardiovascular diseases, respiratory diseases. She is the principal investigator of the H3AbioNet Pasteur du Maroc Node. As an active and lead member in various associations, she also works as part of the H3Africa consortium and the Africa Biogenome project (AfricaBP) to meet the needs in genomics, data analysis, and biological mechanisms exploration, sharing knowledge. She is a vital member of the African Precision Medicine Initiative and African Genomic Medicine Training (AGMT) Planning team. Mr. Lyndon Zass is a Project Manager at the Computational Biology Division of the University of Cape Town in South Africa. With a background in Molecular Biology and Human Genetics, he holds an MSc in Human Genetics, which he obtained from Stellenbosch University. Lyndon is the project manager for the African Genomics Data Hub and co-leads the eLwazi Open Data Science Platform’s Data Support Working Group. In these roles, he manages projects involving the development of African genomics resources and capacity on the continent. He regularly engages with the DS-I Africa consortium about harmonizing disparate health datasets, facilitating the application of data models and FAIR (Findable, Accessible, Interoperable, Reusable) principles. Prof. Faisal Fadlelmola was the principal investigator of the NIH-funded H3ABioNet Sudan Node (July 2012-June 2024) and a key member of the African Precision Medicine Initiative and the African Genomic Medicine Training (AGMT) Planning Team. He is an accomplished academic and research leader with extensive experience in health genomics, bioinformatics, computer science, biotechnology, and life sciences. He completed his postdoctoral fellowship in Cancer Genomics and Bioinformatics at the Centre for Translational and Applied Genomics (CTAG) in British Columbia Cancer Agency, Vancouver, Canada. Prof. Fadlelmola is a passionate advocate for genomic medicine, bioinformatics, open science, and scientific capacity-building in Africa. He has played a leading role in training early-career researchers, shaping policy through evidence-based science, and building sustainable research communities. He currently serves as the Secretary-General of the African Society for Bioinformatics and Computational Biology - ASBCB (March 2020 to present), and leads initiatives that link scientific knowledge with community empowerment and equitable innovation.
Inhaltsangabe
Ch 1: Introduction.- Part 1 Non-communicable Diseases.- Ch 2 Current Status of Precision Medicine Practices for Cardiovascular Diseases in Africa.- Ch 3 The Genetics of Metabolic Syndrome in Africa - Towards Precision Medicine.- Ch 4 The Genetics and Pharmacogenetics of Diabetes in Africa - Towards Personal Diabetes Care.- Ch 5 Precision Oncology.- Ch 6 Precision Medicine of Mental Disorders in Africa.- Ch 7 Precision Medicine of Rare Genetic Diseases in Africa.- Ch 8 The Role of Precision Medicine in Sickle Cell Disease.- Part 2 Communicable diseases.- Ch 9 The Role of Precision Medicine in Malaria - An Innovative Treatment Approach.- Ch 10 Precision Medicine of Hepatitis C Virus in Africa.- Ch 11 Precision Medicine of HIV/AIDS in Africa.- Ch 12 Precision Medicine of TB in Africa.- Part 3 Bioinformatics tools and databases.- Ch 13 New Genomic Technologies and Bioinformatics Resources For Precision Medicine.- Ch 14 Conclusion.
Ch 1: Introduction.- Part 1 Non-communicable Diseases.- Ch 2 Current Status of Precision Medicine Practices for Cardiovascular Diseases in Africa.- Ch 3 The Genetics of Metabolic Syndrome in Africa - Towards Precision Medicine.- Ch 4 The Genetics and Pharmacogenetics of Diabetes in Africa - Towards Personal Diabetes Care.- Ch 5 Precision Oncology.- Ch 6 Precision Medicine of Mental Disorders in Africa.- Ch 7 Precision Medicine of Rare Genetic Diseases in Africa.- Ch 8 The Role of Precision Medicine in Sickle Cell Disease.- Part 2 Communicable diseases.- Ch 9 The Role of Precision Medicine in Malaria - An Innovative Treatment Approach.- Ch 10 Precision Medicine of Hepatitis C Virus in Africa.- Ch 11 Precision Medicine of HIV/AIDS in Africa.- Ch 12 Precision Medicine of TB in Africa.- Part 3 Bioinformatics tools and databases.- Ch 13 New Genomic Technologies and Bioinformatics Resources For Precision Medicine.- Ch 14 Conclusion.
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