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Please note that the content of this book primarily consists of articles available from Wikipedia or other free sources online. Premature Ovarian Failure (POF), also known as primary ovarian insufficiency (this is the most accurate term as some women may still conceive), premature menopause, primary ovarian failure, hypergonadotropic hypogonadism, as well as gonadal dysgenesis, is the loss of function of the ovaries before age 40. A commonly cited triad for the diagnosis is amenorrhea, hypergonadotropinism, and hypoestrogenism.