Providing guidance for chemists and other scientists entering pharmaceutical discovery and development, this up-to-the-minute reference presents contributions from an international group of nearly 50 renowned researchersa "offering a solid grounding in synthetic "and" physical organic chemistry, and clarifying the roles of various specialties in the development of new drugs. Featuring over 1000 references, tables, and illustrations, "Process Chemistry in the Pharmaceutical Industry" is sure to find its way to the bookshelves of organic, physical, analytical, process, and medicinal chemists and…mehr
Providing guidance for chemists and other scientists entering pharmaceutical discovery and development, this up-to-the-minute reference presents contributions from an international group of nearly 50 renowned researchersa "offering a solid grounding in synthetic "and" physical organic chemistry, and clarifying the roles of various specialties in the development of new drugs. Featuring over 1000 references, tables, and illustrations, "Process Chemistry in the Pharmaceutical Industry" is sure to find its way to the bookshelves of organic, physical, analytical, process, and medicinal chemists and biochemists; pharmacists; and upper-level undergraduate and graduate students in these disciplines.
Overview Process Chemistry in the Pharmaceutical Industry: An Overview, Kumar G. Gadamasetti Strategy Process Research and Development Strategy for Accelerated Projects, Christopher M. Cimarusti Case Studies A Practical Synthesis of Ifetroban Sodium, Richard H. Mueller Synthesis of 5-Lipoxygenase Inhibitors, Ivan Lantos and Richard Matsuoka Chemistry of Vitamin D: A Challenging Field for Process Research, Masami Okabe A Highly Optimized and Concise Large Scale Synthesis of a Purine Bronchodilator, Hans-Jürgen Federsel and Edib Jakupovic Ontazolast: The Evolution of a Process, Vittorio Farina, Karl Grozinger, Hermann Müller-Bötticher and Gregory P. Roth Dilevalol Hydrochloride: Development of a Commercial Process, Derek Walker Design and Development of Practical Syntheses of LY228729, a Potent 5HT1a Receptor Agonist, Michael J. Martinelli and David L. Varie Process Research and Development of CGS 19755, an NMDA Antagonist, Peter Giannousis, John Carlson and Marius Leimer Route Evaluation for the Production of (R)-Levoprotiline, H. U. Blaser, R. Gamboni, B. Pugin, G. Rihs, G. Sedelmeier, E. Schaub, E. Schmidt, B. Schmitz, F. Spindler and Hj. Wetter The Process Research and Development of DuPont Merck's Cyclic Urea Diols, A New Class of HIV Protease Inhibitors, Pat N. Confalone and Robert E. Waltermire Practical Enantio- and Diastereo-selective Processes for Azetidinones, T. K. Thiruvengadam, Anantha R. Sudhakar, and Guangzhong Wu Synthesis of the Common Lactone Moiety of HMG-CoA Reductase Inhibitors, Ian M. McFarlane, Christopher G. Newton and Philippe Pitchen Enzymatic Intervention and Phase Transfer Catalysis Chemistry, Biocatalysis and Engineering: An Interdisciplinary Approach to the Manufacture of the Benzodiazepine Drug Candidate LY 300164, Benjamin A. Anderson, Marvin M. Hansen, Jeffrey T. Vicenzi and Milton J. Zmijewski Benefits and Challenges of Applying Phase-Transfer Catalysis Technology in the Pharmaceutical Industry, Marc E. Halpern Asymmetric Synthesis and Enantioselectivity Enantioselective Synthesis: The Optimum Process, John J. Partridge and Brian L. Bray Practical Catalysts for Asymmetric Synthesis: Ligands from Natural Sugars for Rh-Catalyzed Asymmetric Synthesis of D- and L- Amino Acids, Timothy A. Ayers and T. V. Rajan Babu Chiral (Salen)Mn(III) Complexes in Asymmetric Epoxidations: Practical Synthesis of cis-Aminoindanol and Its Application to Enantiopure Drug Synthesis, Chris H. Senanayake and Eric N. Jacobsen Drug Substance Final Form and Process Safety Chemical Development of the Drug Substance Solid Form, Michael D. Thompson and Jean-René Authelin The Basic Principles of Thermal Process Safety: Towards a Better Communication Between Safety Experts and Process Chemists, Wilfried Hoffmann Design of Experiments and Automation Using Factorial Experiments in the Development of Process Chemistry, Daniel R. Pilipauskas Laboratory Automation in Chemical Development, Martin R. Owen and Sheila H. Dewitt
Overview Process Chemistry in the Pharmaceutical Industry: An Overview, Kumar G. Gadamasetti Strategy Process Research and Development Strategy for Accelerated Projects, Christopher M. Cimarusti Case Studies A Practical Synthesis of Ifetroban Sodium, Richard H. Mueller Synthesis of 5-Lipoxygenase Inhibitors, Ivan Lantos and Richard Matsuoka Chemistry of Vitamin D: A Challenging Field for Process Research, Masami Okabe A Highly Optimized and Concise Large Scale Synthesis of a Purine Bronchodilator, Hans-Jürgen Federsel and Edib Jakupovic Ontazolast: The Evolution of a Process, Vittorio Farina, Karl Grozinger, Hermann Müller-Bötticher and Gregory P. Roth Dilevalol Hydrochloride: Development of a Commercial Process, Derek Walker Design and Development of Practical Syntheses of LY228729, a Potent 5HT1a Receptor Agonist, Michael J. Martinelli and David L. Varie Process Research and Development of CGS 19755, an NMDA Antagonist, Peter Giannousis, John Carlson and Marius Leimer Route Evaluation for the Production of (R)-Levoprotiline, H. U. Blaser, R. Gamboni, B. Pugin, G. Rihs, G. Sedelmeier, E. Schaub, E. Schmidt, B. Schmitz, F. Spindler and Hj. Wetter The Process Research and Development of DuPont Merck's Cyclic Urea Diols, A New Class of HIV Protease Inhibitors, Pat N. Confalone and Robert E. Waltermire Practical Enantio- and Diastereo-selective Processes for Azetidinones, T. K. Thiruvengadam, Anantha R. Sudhakar, and Guangzhong Wu Synthesis of the Common Lactone Moiety of HMG-CoA Reductase Inhibitors, Ian M. McFarlane, Christopher G. Newton and Philippe Pitchen Enzymatic Intervention and Phase Transfer Catalysis Chemistry, Biocatalysis and Engineering: An Interdisciplinary Approach to the Manufacture of the Benzodiazepine Drug Candidate LY 300164, Benjamin A. Anderson, Marvin M. Hansen, Jeffrey T. Vicenzi and Milton J. Zmijewski Benefits and Challenges of Applying Phase-Transfer Catalysis Technology in the Pharmaceutical Industry, Marc E. Halpern Asymmetric Synthesis and Enantioselectivity Enantioselective Synthesis: The Optimum Process, John J. Partridge and Brian L. Bray Practical Catalysts for Asymmetric Synthesis: Ligands from Natural Sugars for Rh-Catalyzed Asymmetric Synthesis of D- and L- Amino Acids, Timothy A. Ayers and T. V. Rajan Babu Chiral (Salen)Mn(III) Complexes in Asymmetric Epoxidations: Practical Synthesis of cis-Aminoindanol and Its Application to Enantiopure Drug Synthesis, Chris H. Senanayake and Eric N. Jacobsen Drug Substance Final Form and Process Safety Chemical Development of the Drug Substance Solid Form, Michael D. Thompson and Jean-René Authelin The Basic Principles of Thermal Process Safety: Towards a Better Communication Between Safety Experts and Process Chemists, Wilfried Hoffmann Design of Experiments and Automation Using Factorial Experiments in the Development of Process Chemistry, Daniel R. Pilipauskas Laboratory Automation in Chemical Development, Martin R. Owen and Sheila H. Dewitt
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