Protein Engineering for Therapeutics, Part a

Volume 502
Herausgegeben:Wittrup, K. Dane; Verdine, Gregory L.

• Gebundenes Buch

Produktbeschreibung

This volume of Methods in Enzymology looks at Protein Engineering for Therapeutics. The chapters provide an invaluable resource for academics, researchers and students alike. With an international board of authors, this volume is split into sections that cover subjects such as Antibodies, Protein conjugates, Peptides, Enzymes and Scaffolds

Produktdetails

• Methods in Enzymology Volume 502
• Verlag: Academic Press
• Artikelnr. des Verlages: C2010-0-66901-X
• Seitenzahl: 392
• Erscheinungstermin: 11. Januar 2012
• Englisch
• Abmessung: 244mm x 159mm x 28mm
• Gewicht: 748g
• ISBN-13: 9780124160392
• ISBN-10: 0124160395
• Artikelnr.: 34434920

Inhaltsangabe

1. Simplified Synthetic Antibody Libraries



2. Generation of Dual Variable Domain Immunoglobulin Molecules for Dual-specific Targeting



3. Discovery of internalizing antibodies to tumor antigens from phage libraries



4. Optimizing properties of anti-receptor antibodies using kinetic computational models and experiments



5. Cell-specific siRNA delivery by peptides and antibodies



6. Conjugation of Anticancer Drugs Through Endogenous Monoclonal Antibody Cysteine Residues



7. Building and characterizing antibody-targeted lipidic nanotherapeutics



8. Cell-Targeting Fusion Constructs Containing Recombinant Gelonin



9. Stapled Peptides for Intracellular Drug Targets



10. Mapping of vascular zip codes by phage display



11. Engineering cyclic peptide toxins



12. Peptide Discovery using Bacterial Display and Flow Cytometry



13. Oral enzyme therapy for celiac sprue



14. Rational Design and Evaluation of Mammalian Ribonuclease Cytotoxins



15. Engineering Reduced-Immunogenicity Enzymes for Amino Acid Depletion Therapy in Cancer



16. Designed Ankyrin Repeat Proteins (DARPins): From research to therapy



17. Target-binding proteins based on the tenth human fibronectin type III domain (¹⁰Fn3)



18. Anticalins: small engineered binding proteins based on the lipocalin scaffold



19. T Cell Receptor Engineering



20. Engineering Knottins as Novel Binding Agents



21. Re-Engineering Biopharmaceuticals for Targeted Delivery Across the Blood-Brain Barrier



22. Practical Theoretic Guidance for the Design of Tumor Targeting Agents



23. Fusions of elastin-like polypeptides to pharmaceutical proteins



24. Engineering and Identifying Supercharged Proteins for Macromolecule Delivery into Mammalian Cells