This is the first compilation of protein lipidation enzymes. This volume summarizes recent dramatic developments regarding enzymes responsible for protein lipidation, a process critical for a number of physiological functions, including cell proliferation and morphology. Inhibitors of protein lipidation have recently been shown to be useful as anticancer drugs. Enzymatic mechanisms, mutational analysis, and structural studies are presented.
This is the first compilation of protein lipidation enzymes. This volume summarizes recent dramatic developments regarding enzymes responsible for protein lipidation, a process critical for a number of physiological functions, including cell proliferation and morphology. Inhibitors of protein lipidation have recently been shown to be useful as anticancer drugs. Enzymatic mechanisms, mutational analysis, and structural studies are presented.
Fuyu Tamanoi is a biochemist who has served on the UCLA School of Medicine and UCLA College faculty since he joined the Department of Microbiology, Immunology & Molecular Genetics in 1993. He became a full professor in 1997.
Inhaltsangabe
Mechanism of Catalysis by Protein Farnesyltransferase Structure of Protein Farnesyltransferase Mutational Analyses of Protein Farnesyltransferase Farnesyltransferase Inhibitors Protein Geranylgeranyltransferase Type I Biochemistry of Rab Geranylgeranyltransferase Postisoprenylation Protein Processing: CXXX (CaaX) Endoproteases and Isoprenylcysteine Carboxyl Methyltransferase Reversible Modification of Proteins with Thioester-Linked Fatty Acids Biology and Enzymology of Protein N-Myristoylation
Mechanism of Catalysis by Protein Farnesyltransferase Structure of Protein Farnesyltransferase Mutational Analyses of Protein Farnesyltransferase Farnesyltransferase Inhibitors Protein Geranylgeranyltransferase Type I Biochemistry of Rab Geranylgeranyltransferase Postisoprenylation Protein Processing: CXXX (CaaX) Endoproteases and Isoprenylcysteine Carboxyl Methyltransferase Reversible Modification of Proteins with Thioester-Linked Fatty Acids Biology and Enzymology of Protein N-Myristoylation
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