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Psychological phenomena are understood with respect to the way in which cultural and social environments influence them, which is not unrelated to the possibility of measuring and comparing behavior. With the aim of analyzing psychological adjustment in adolescents with drug dependence, a mixed study was conducted in which statistically significant differences were found between a control group and the group of adolescents with drug dependence: in six of nine psychological adjustment traits evaluated, the same traits that presented dependence to drug dependence. Among these traits, the most representative scores were impulsivity, subjectivity and hostility. Most described growing up in hostile environments and adequate psychological adjustment in social, artistic and sporting activities.