Suitable for cancer clinicians and biostatisticians, this book explains how to properly select and accurately use diverse statistical methods for designing and analyzing phase II trials. The author first reviews the statistical methods for single-arm phase II trials since some methodologies for randomized phase II trials stem from single-arm pha
Suitable for cancer clinicians and biostatisticians, this book explains how to properly select and accurately use diverse statistical methods for designing and analyzing phase II trials. The author first reviews the statistical methods for single-arm phase II trials since some methodologies for randomized phase II trials stem from single-arm pha
Sin-Ho Jung is a professor of biostatistics and bioinformatics at Duke University School of Medicine. He earned a PhD from the University of Wisconsin-Madison. His research interests include clinical trial design, survival analysis, longitudinal data analysis, clustered data analysis, ROC curve analysis, and microarray studies.
Inhaltsangabe
Introduction. Single-Arm Phase II Trial Designs. Inference on the Binomial Probability in Single-Arm Multistage Clinical Trials. Single-Arm Phase II Clinical Trials with Time-to-Event Endpoints. Single-Arm Phase II Trials with Heterogeneous Patient Populations: Binary and Survival Outcomes. Randomized Phase II Trials for Selection: No Prospective Control Arms. Randomized Phase II Cancer Clinical Trials with a Prospective Control on Binary Endpoints (I): Two-Sample Binomial Test. Randomized Phase II Cancer Clinical Trials with a Prospective Control on Binary Endpoints (II): Fisher's Exact Test. Randomized Phase II Trials with Heterogeneous Patient Populations: Stratified Fisher's Exact Test. Randomized Phase II Clinical Trials Based on Survival Endpoints: Two-Sample Log-Rank Test. Some Flexible Phase II Clinical Trial Designs. Index.
Introduction. Single-Arm Phase II Trial Designs. Inference on the Binomial Probability in Single-Arm Multistage Clinical Trials. Single-Arm Phase II Clinical Trials with Time-to-Event Endpoints. Single-Arm Phase II Trials with Heterogeneous Patient Populations: Binary and Survival Outcomes. Randomized Phase II Trials for Selection: No Prospective Control Arms. Randomized Phase II Cancer Clinical Trials with a Prospective Control on Binary Endpoints (I): Two-Sample Binomial Test. Randomized Phase II Cancer Clinical Trials with a Prospective Control on Binary Endpoints (II): Fisher's Exact Test. Randomized Phase II Trials with Heterogeneous Patient Populations: Stratified Fisher's Exact Test. Randomized Phase II Clinical Trials Based on Survival Endpoints: Two-Sample Log-Rank Test. Some Flexible Phase II Clinical Trial Designs. Index.
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