Recent Advances in Parkinsons Disease

Recent Advances in Parkinsons Disease

Part II: Translational and Clinical Research Volume 184
Herausgegeben:Bjorklund, Anders; Cenci-Nilsson, Angela

• Gebundenes Buch

Produktbeschreibung

This second volume follows on from Part I by reviewing the variety of animal models of PD current available (from drosophila to rodents to non-human primate species) and their specific contributions to PD research. This is followed by comprehensive coverage of functional neuroimaging studies that explore different pathophysiological questions and evaluate treatment outcome in PD patients. Different areas of experimental therapeutics and outstanding challenges to PD treatment are presented in a concluding group of articles.

Produktdetails

• Progress in Brain Research Volume 184
• Verlag: Elsevier Books
• Artikelnr. des Verlages: C2009-0-01804-2
• Seitenzahl: 368
• Erscheinungstermin: 24. November 2010
• Englisch
• Abmessung: 244mm x 200mm x 24mm
• Gewicht: 924g
• ISBN-13: 9780444537508
• ISBN-10: 0444537503
• Artikelnr.: 31892579

Autorenporträt

As a neuroanatomist and developmental neurobiologist, during the 1970s Björklund's lab originated reliable methods for transplantation of embryonic tissues into brain that pioneered practical cell transplantation in the central nervous system, providing the basis for technologies that are now used by laboratories world-wide. In parallel, work in the field has progressed from basic anatomical and developmental studies in experimental animals, via applications for assessing cell replacement and repair using primary and stem cells in the damaged brain, and now underpinning the majority of methods in development for cell therapy in patients. His laboratory continues to analyse the fundamental neurobiology and principles of cell transplantation, regeneration and integration in the CNS, as well as originating the first trials of effective clinical cell transplantation (for Parkinson's disease) in patients

Inhaltsangabe

Section I: Animal models of PD

1. What have we learned from Drosophila Models of Parkinson's Disease? - Ming Guo



2. Neurotoxic in vivo models of Parkinson's disease: recent advances - Timothy Greenamyre & Jason R. Cannon



3. Behavioural analysis of motor and non-motor symptoms in rodent models of Parkinson's disease - Stephen B. Dunnett & Mariah Lelos



4. Genetic mouse models of Parkinson's disease: the state of the art - Marie-Francoise Chesselet & Iddo Magen



5. Viral vector mediated overexpression of a-synuclein as a progressive model of Parkinson's disease - Anders Bjorklund, Ayse Ulusoy, Mickael Decressac, Deniz Kirik



6. Modelling inflammatory pathogenesis of Parkinson's Disease - Malu Tansey & Christopher J. Barnum



7. The MPTP-lesioned non-human primate models of Parkinson's disease. Past, present and future - Susan Fox & Jonathan Brotchie


Section II: Exploring PD with brain imaging


8. Abnormal Metabolic Brain Networks in Parkinson's Disease: From Blackboard to Bedside - David Eidelberg & Chris C. Tang



9. Imaging the Nigrostriatal System to Monitor Disease Progression and Treatment-Induced Complications - Jon Stoessl & Renju Kuriakose



10. Brain imaging after neural transplantation - Paola Piccini & Marios Politis



11. Imaging non-motor aspects of Parkinson's disease - David Brooks & Nicola Pavese


Section III: Frontiers in PD treatment


12. Gene therapy for dopamine replacement - Deniz Kirik & Tomas Björklund, Erik Ahlm Cederfjäll



13. Neurotrophic Factor Therapy for Parkinson's disease - Jeffrey Kordower, Rangasamy Suresh Babu, Katherine Soderstrom, Roy A.E. Bakay



14. Neural grafting in Parkinson's disease: Problems and possibilities - Patrik Brundin, Roger A Barker and Malin Parmar



15. Neural grafting in Parkinson´s disease: Unraveling the mechanisms underlying graft-induced dyskinesia - Emma L Lane, Anders Björklund, Stephen B Dunnett, Christian Winkler



16. Deep Brain Stimulation: State of the Art and Novel Stimulation Targets - Andres Lozano & Francisco A. Ponce



17. The challenge of Non-Motor Symptoms in Parkinson´s Disease - Ray Chaudhuri & Per Odin