The eight publications in this Special Issue focus on advancing therapeutic strategies specifically tailored to pediatric patients. Despite addressing a wide range of conditions (including fungal infections, cancer, spinal muscular atrophy, sleep-disordered breathing, and drug-induced cardiotoxicity), they share a common goal: to improve the safety, efficacy, and personalization of pediatric therapies. Several studies highlight the importance of appropriate dosing, formulation stability, and bioavailability (e.g., fluconazole, AmBisome®, and temozolomide), emphasizing the challenges of adapting adult medications for children and the need for age-specific drug testing to minimize the risks associated with off-label prescribing. Gene therapy and precision medicine also emerge as key themes, showcasing innovative therapeutic approaches. Finally, the Special Issue reflects a clear shift toward patient-centered care, promoting safer drug delivery, improved monitoring (e.g., through cardiotoxicity biomarkers), and more evidence-based treatment protocols for children. Collectively, these studies underscore the critical need to design and validate pediatric therapies based on the unique physiological and developmental characteristics of this population.
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