Reticulocytosis as a Surrogate Marker of Recent Pf Malaria Infection - Okoth, Patrick
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Reticulocytosis is an important previously unappreciated surrogate marker of recent Plasmodium falciparum reticulocyte parasitation. Evidence from studies in murine and primate models show increased prevalence of Plasmodium falciparum parasitisation of reticulocytes. The increase in reticulocyte infection has been attributed to compensatory reticulocytosis and increased parasite densities. However, the prevalence of P. falciparum parasitisation of reticulocytes in human populations in holoendemic areas of malaria is unknown. Therefore, the current study examined the prevalence of P. falciparum…mehr

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Produktbeschreibung
Reticulocytosis is an important previously unappreciated surrogate marker of recent Plasmodium falciparum reticulocyte parasitation. Evidence from studies in murine and primate models show increased prevalence of Plasmodium falciparum parasitisation of reticulocytes. The increase in reticulocyte infection has been attributed to compensatory reticulocytosis and increased parasite densities. However, the prevalence of P. falciparum parasitisation of reticulocytes in human populations in holoendemic areas of malaria is unknown. Therefore, the current study examined the prevalence of P. falciparum parasitation of reticulocytes and its association with clinical, parasitological and haematological outcomes in children and adults with acute P. falciparum malaria and healthy malaria -ve controls from a holoendemic area of malaria of western Kenya.Results of this study demonstrate higher prevalence of reticulocyte parasitation in children. Thus, it seems likely that P. falciparum reticulocyte parasitation leads to a burst in compensatory reticulocytosis in acute paediatric malaria predictable by HDP and a febrile illness among children
Autorenporträt
Der Autor ist Experte für öffentliche Gesundheit und verfügt über mehr als 20 Jahre Berufserfahrung in den Bereichen Entwicklung und Notfallhilfe in über zehn Entwicklungsländern, wo er mit Nichtregierungsorganisationen und UN-Organisationen zusammengearbeitet hat. Derzeit promoviert er im Bereich öffentliche Gesundheit mit den Schwerpunkten Politikentwicklung, -formulierung und -umsetzung.