Hosna Moustafa, Gihan El-Hennawy, Esraa El-kholy

Role Of Fdg Pet-ct In Evaluation Of Gastrointestinal Stromal Tumors

• Broschiertes Buch

Produktbeschreibung

Gastrointestinal stromal tumors (GISTs) are the most frequent mesenchymal tumors of the gastrointestinal tract. A definition of a new entity among the gastrointestinal mesenchymal tumors called the gastrointestinal stromal tumors (GISTs) which express the kit (CD117) protein a growth factor trans-membrane receptor with tyrosine kinase activity. Surgery is the mainstay of therapy for non-metastatic GISTs. The c-kit tyrosine kinase inhibitor Imatinib (Glivec), was found to be useful in treating GISTs, leading to a 40-70% response rate in metastatic or inoperable cases.The current Response Evaluation Criteria in solid tumors are based on uni-dimensional tumor size, and do not take into account changes in responding GISTs such as a decrease in tumor density and decrease in the number of intra-tumoral vessels with CT. PET/CT is highly sensitive in assessment early response to Imatinib mesylate. Also, it is useful in predicting long-term response to imatinib in patients with metastaticGIST; however, widespread use of PET is limited because of cost constraints.

Produktdetails

• Verlag: LAP Lambert Academic Publishing
• Seitenzahl: 72
• Erscheinungstermin: 10. Juli 2017
• Englisch
• Abmessung: 220mm x 150mm x 5mm
• Gewicht: 125g
• ISBN-13: 9783330326125
• ISBN-10: 3330326123
• Artikelnr.: 48881878

Autorenporträt

H. Moustafa: Dottorato, Università del Cairo, Egitto, novembre 1979. Professore di medicina nucleare all'Università del Cairo. Responsabile del progetto AFRA di Medicina Nucleare in Egitto (2003-2030). Supervisione di 146 tesi di laurea in Medicina Nucleare. 50 pubblicazioni internazionali. Responsabile della Società egiziana di NM e della rivista di medicina nucleare ESNMS, dal 2008 a oggi.