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With all the characteristics of an ideal diagnostic instrument, saliva is a fascinating biological fluid. Its acquisition is actually quick, straightforward, and non-invasive. Due to its close contact with crevicular fluid and a number of transportation methods, saliva contains hundreds of plasma-derived proteins. Advances in analytical methods have made it possible to identify and quantify these proteins with greater accuracy. pioneered a new field known as salivaomics, which studies the salivary microbiome, metabolome, microRNAs, transcriptome, and proteome.