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The landscape of healthcare is rapidly evolving with the integration of smart technologies, data analytics, and artificial intelligence (AI). This comprehensive review explores the latest advancements in smart healthcare systems and their applications, emphasizing research findings, implications, and future directions.The review begins by defining the scope of smart healthcare research, highlighting its interdisciplinary nature and potential to revolutionize healthcare delivery. It examines key research methodologies employed in healthcare technology, including IoT, machine learning, big data analytics, blockchain, and wearable sensor technologies, elucidating their roles in enhancing patient care, disease management, and wellness promotion.