This book provides a comprehensive understanding of the transformative potential of stem cell therapies for improving skin health and treating debilitating dermatological disorders. Stem Cell Therapy in Dermatological Disorders delves into the emerging field of stem cell therapy as a revolutionary approach to treating various dermatological conditions. This book provides a comprehensive overview of the science behind stem cell technology, focusing on its applications in skin regeneration, wound healing, and the management of chronic skin diseases. It examines the cellular and molecular…mehr
This book provides a comprehensive understanding of the transformative potential of stem cell therapies for improving skin health and treating debilitating dermatological disorders. Stem Cell Therapy in Dermatological Disorders delves into the emerging field of stem cell therapy as a revolutionary approach to treating various dermatological conditions. This book provides a comprehensive overview of the science behind stem cell technology, focusing on its applications in skin regeneration, wound healing, and the management of chronic skin diseases. It examines the cellular and molecular mechanisms that make stem cells uniquely suited for dermatological use, exploring their ability to promote tissue repair, modulate inflammation, and restore the skin's structural integrity. This book aims to bridge the gap between experimental research and clinical application, presenting up-to-date findings on the different types of stem cells used in dermatology, including mesenchymal stem cells, induced pluripotent stem cells, and embryonic stem cells. It highlights the role of stem cells in addressing disorders such as atopic dermatitis, psoriasis, vitiligo, and chronic non-healing wounds. Readers will find in-depth discussions on current therapeutic techniques, the challenges of translating preclinical studies to human trials, and the ethical considerations associated with stem cell therapies. In addition to discussing the state-of-the-art in stem cell-based treatments, the book also casts an eye on the future, identifying gaps in existing knowledge and potential areas for innovation. The authors provide insights into novel delivery systems, genetic engineering advancements, and combinatory approaches that may enhance the efficacy and safety of stem cell therapies in dermatology. This volume serves as an essential resource for dermatologists, researchers, and clinicians seeking to understand the transformative potential of stem cell therapies in improving skin health and treating debilitating dermatological disorders. Readers will find the book: * Explores the latest breakthroughs in stem cell therapy for skin disorders; * Bridges the gap between basic science and clinical applications; * Discusses mesenchymal stem cells (MSCs), iPSCs, and exosome-based therapies. Audience Dermatologists, dermatopathologists, plastic surgeons, medical aestheticians, researchers, clinicians, and biotechnology and pharmaceutical professionals involved in regenerative medicine and aesthetic dermatology.
Sumel Ashique is an assistant professor at Bharat Technology, India with four years of teaching experience. He has published over 80 articles in national and international journals, 20 book chapters, 14 books, and five patents. His research focuses on drug delivery, nanotechnology, and targeted treatment strategies. Sanjay Dey, PhD is a professor in the Department of Pharmaceutical Technology in the School of Health and Medical Sciences at Adamas University, India with over 15 years of experience. He has published 31 research articles and 11 review articles in national and international journals, eight book chapters, and five patents. His research interests include the development of conventional drug delivery systems and novel drug delivery systems. Biplab Debnath, PhD is a distinguished principal and professor at Bharat Technology, India. He has published over 60 research and review papers in international journals, five book chapters, eight books, and two granted patents. His research expertise lies in silico synthesis and the biological activities of novel heterocyclic molecules. Mohhammad Ramzan, PhD of the School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab, India, has over ten years of teaching and research experience. He has over 36 publications in reputed national and international journals, four book chapters, and five copyrights. His research focuses on nanoparticulates and vesicular drug delivery systems. Swarupananda Mukherjee, PhD is an associate professor and Head of the Department, Pharmaceutics Department, NSHM Knowledge Campus, Kolkata, College of Pharmaceutical Technology, Kolkata, India and has over 18 years of teaching and research experience. He has over 85 publications in reputed national and international journals, 20 books, and 15 patents. His research focuses on nanoparticulate drug delivery systems.
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Preface xv 1 Fundamentals of Stem Cell Therapy in Disease Prevention 1 Rajarshi Nath, Arijit Das, Shambo Panda, Souvik Biswas and Biplab Debnath 1.1 Introduction to Stem Cell Therapy 2 1.2 Mechanisms of Stem Cell Therapy 4 1.3 Applications of Stem Cell Therapy in Disease Prevention 8 1.4 Challenges and Limitations of Stem Cell Therapy 11 1.5 Future Perspectives and Innovations 14 2 Stem Cell Therapy on Skin: Mechanisms and Recent Advances 19 Koushik Jana, Md. Kabirul Islam Mollah, Gouranga Dutta, Goutam Ghosh and Goutam Rath 2.1 Background and Historical Overview of Stem Cell Therapy 20 2.2 Skin Diseases and Stem Cell Treatment 21 2.3 Types of Stem Cells and Their Mechanism in Skin Diseases 27 2.4 Recent Advancements in Skin Disease Stem Cell Therapy 30 2.5 Challenges and Regulatory Aspects 34 2.6 Conclusion and Future Outlooks 34 3 Stem Cell Therapy: Significant Option for Psoriasis Management 43 Joy Das, Utpal Bhui, Saistha Anjum, Sumel Ashique, Mohammad Muztaba and Sanjay Dey 3.1 Introduction 44 3.2 Advantages of Stem Cell Therapy for Psoriasis 46 3.3 Types of Stem Cell Therapy in Psoriasis 48 3.4 Therapeutic Value of Stem Cell 51 3.5 Challenges in Cost, Availability, and Clinical Application 60 3.6 Regulatory Aspects of Stem Cell Therapy 64 3.7 Conclusion and Future Directions 65 4 Therapeutic Modalities of Stem Cells: Skin Cancer Treatment 79 Dipanjan Karati, Soumi Das and Swarupananda Mukherjee 4.1 Introduction 80 4.2 Stem Cells in Skin Cancer: A Brief Overview 81 4.3 Therapeutic Modalities of Stem Cells in Skin Cancer Treatment 83 4.4 Emerging Trends and Advanced Technologies in Stem Cell Therapy for Skin Cancer 90 4.5 Challenges and Limitations of Stem Cell-Based Therapies 95 4.6 Preclinical and Clinical Studies: Insights and Outcomes 96 4.7 Future Directions and Perspectives 97 4.8 Conclusion 98 5 Therapeutic Advancement of Stem Cell Therapy in Atopic Dermatitis 109 Kishanta Kumar Pradhan, Rojalin Samanta, Reechik Bandyopadhyay, Arnab Seth and Chowdhury Mobaswar Hossain 5.1 Background of Atopic Dermatitis 110 5.2 Stem Cell Biology and Mechanisms 111 5.3 Types and Pathophysiology of AD 120 5.4 Different Stem Cell Application on AD 122 5.5 Challenges and Ethical Considerations 125 5.6 Recent Advancement of Stem Cell Therapy on AD 128 5.7 Clinical Research Updates 130 6 Stem Cell Therapy: A Significant Therapeutic Approach in Wound Healing 141 Richa Dayaramani, Soma Jana, Bratati Bandyopadhyay, Amlan Bishal and Subhashis Debnath 6.1 Introduction 142 6.2 Physiology of Wound-Healing Process 143 6.3 Biology of Stem Cells and their Role in Wound Healing 145 6.4 Stem Cell Therapy for Wound Healing and Histopathological Studies 148 6.5 Stem Cell Delivery Mechanisms for Wound Healing 148 6.6 Clinical Uses of Stem Cell Therapy in Wound Healing 149 6.7 Recent Developments and Technologies in Stem Cell Research for Wound Healing 150 6.8 Challenges in Stem Cell Treatment 151 6.9 Potential Future Applications of Stem Cell-Derived Products in the Use of Stem Cells for Wound Healing 154 6.10 Conclusion 157 7 Stem Cell Therapy: Skin Aging Blocking 163 Dipanjana Ash, Sohini Sen, Sneha Shaw, Ayon Dutta, Leena Kumari and Swarupananda Mukherjee 7.1 Introduction 164 7.2 Stem Cell: An Overview 165 7.3 Mechanisms of SC Action in Skin Regeneration 170 7.4 Preclinical Applications of SC in Skin Aging 173 7.5 Clinical Applications of SC in Skin Aging 175 7.6 Challenges and Considerations 177 7.7 Future Directions and Innovations 181 7.8 Conclusion 182 8 Future Window of Stem Cells in Skin Regeneration and Rejuvenation: Current Status and Future Aspect 195 Vivek Barik, Bramhajit Chatterjee, Snigdha Chatterjee, Swarupananda Mukherjee and Piyali Khamkat 8.1 Introduction 196 8.2 Types of SCs Used in Skin Regeneration and Rejuvenation 198 8.3 Emerging Technologies and Innovations 202 8.4 Challenges in SC-Based Therapies 205 8.5 Future Directions of SCs in Skin Regeneration and Rejuvenation 206 8.6 Current Clinical Trials Updates 208 8.7 Regulatory Challenges for SC-Based Therapies 210 8.8 Conclusion 211 9 Stem Cell Therapy in Dermatology: Challenges and Opportunities 219 Garima Chandak, Sumel Ashique, Shubham Kumar, Narendra Kumar Pandey, Dileep Singh Baghel, Bimlesh Kumar, Saurabh Singh and Omji Porwal 9.1 Introduction 220 9.2 Types of Stem Cells in Dermatology 224 9.3 Mechanisms of Action 225 9.4 Current Applications of Stem Cell Therapy in Dermatology 230 9.5 Advances in Stem Cell Delivery Systems 235 9.6 Challenges in Stem Cell Therapy for Dermatology 238 9.7 Opportunities and Emerging Trends 242 9.8 Preclinical and Clinical Studies 246 9.9 Regulatory and Ethical Considerations 255 9.10 Future Directions 256 9.11 Conclusion 257 10 Clinical Significance and Regulatory Aspects of Stem Cell Therapy 271 Debasmita Paul, Karan Kr. Das, Abhijit Ghosh, Soukat Chandra and Shaileyee Das 10.1 Introduction 272 10.2 Definition and Types of Stem Cells 274 10.3 Mechanisms of Action of Stem Cell Therapy 276 10.4 Future Perspectives 291 10.5 Conclusions and Future Directions 293 11 Translational Research for Dermatological Stem Cell Therapy 301 Mishra Bharti, Khan Anam, Gothalwal Ragini, Jaiswal Prashansa and Kotnis Ashwin 11.1 Introduction 301 11.2 Mechanism of Stem Cell Action in Skin Regeneration and Healing 304 11.3 Current Applications of Stem Cell Therapy in Dermatology 307 11.4 Safety and Challenges in Translating Stem Cell Research to Clinical Practice 310 11.5 Conclusion and Prospects for the Future 312 12 In Vitro and In Vivo Model of Stem Cell Therapy in Dermatological Diseases 321 Sneha Das, Pradip Jana, Mohini Mondal, Mainak Chatterjee and Moitreyee Chattopadhyay 12.1 Introduction 322 12.2 Current and Future Perspectives of SC Therapy in Dermatology by In Vitro and In Vivo Models 325 12.3 In Vitro Models for SC Therapy in Dermatological Diseases 328 12.4 Various Animal Model for In Vivo in Dermatological Diseases 331 12.5 Analytical and Numerical Solutions to the Various Models 334 12.6 Conclusions and Future Directions 335 13 Preclinical and Clinical Trials and Case Studies Involved in Stem Cell Therapy in Dermatological Diseases 341 Rony Mandal, Somali Gorai and Sajal Kumar Jha 13.1 Introduction 342 13.2 Forms of Stem Cell Therapy 343 13.3 Role of Autoimmune System in Dermatological Skin Problem 347 13.4 Therapeutic Value of Stem Cell in Different Allergic Skin Disease 350 13.5 Role of Cutaneous Stem Cells in Regeneration of Different Tissues 352 13.6 Advantages of Stem Cell Therapy for Different Dermatological Diseases 354 13.7 Different In Vivo and In Vitro Models for Preclinical SCT 356 13.8 Preclinical Test Method for Different Skin Disease 360 13.9 FDA-Approved Clinical Phase Trial Drugs for Dermatological Disease 364 13.10 Conclusions and Future Directions 365 References 366 Bibliography 370 Index 371
Preface xv 1 Fundamentals of Stem Cell Therapy in Disease Prevention 1 Rajarshi Nath, Arijit Das, Shambo Panda, Souvik Biswas and Biplab Debnath 1.1 Introduction to Stem Cell Therapy 2 1.2 Mechanisms of Stem Cell Therapy 4 1.3 Applications of Stem Cell Therapy in Disease Prevention 8 1.4 Challenges and Limitations of Stem Cell Therapy 11 1.5 Future Perspectives and Innovations 14 2 Stem Cell Therapy on Skin: Mechanisms and Recent Advances 19 Koushik Jana, Md. Kabirul Islam Mollah, Gouranga Dutta, Goutam Ghosh and Goutam Rath 2.1 Background and Historical Overview of Stem Cell Therapy 20 2.2 Skin Diseases and Stem Cell Treatment 21 2.3 Types of Stem Cells and Their Mechanism in Skin Diseases 27 2.4 Recent Advancements in Skin Disease Stem Cell Therapy 30 2.5 Challenges and Regulatory Aspects 34 2.6 Conclusion and Future Outlooks 34 3 Stem Cell Therapy: Significant Option for Psoriasis Management 43 Joy Das, Utpal Bhui, Saistha Anjum, Sumel Ashique, Mohammad Muztaba and Sanjay Dey 3.1 Introduction 44 3.2 Advantages of Stem Cell Therapy for Psoriasis 46 3.3 Types of Stem Cell Therapy in Psoriasis 48 3.4 Therapeutic Value of Stem Cell 51 3.5 Challenges in Cost, Availability, and Clinical Application 60 3.6 Regulatory Aspects of Stem Cell Therapy 64 3.7 Conclusion and Future Directions 65 4 Therapeutic Modalities of Stem Cells: Skin Cancer Treatment 79 Dipanjan Karati, Soumi Das and Swarupananda Mukherjee 4.1 Introduction 80 4.2 Stem Cells in Skin Cancer: A Brief Overview 81 4.3 Therapeutic Modalities of Stem Cells in Skin Cancer Treatment 83 4.4 Emerging Trends and Advanced Technologies in Stem Cell Therapy for Skin Cancer 90 4.5 Challenges and Limitations of Stem Cell-Based Therapies 95 4.6 Preclinical and Clinical Studies: Insights and Outcomes 96 4.7 Future Directions and Perspectives 97 4.8 Conclusion 98 5 Therapeutic Advancement of Stem Cell Therapy in Atopic Dermatitis 109 Kishanta Kumar Pradhan, Rojalin Samanta, Reechik Bandyopadhyay, Arnab Seth and Chowdhury Mobaswar Hossain 5.1 Background of Atopic Dermatitis 110 5.2 Stem Cell Biology and Mechanisms 111 5.3 Types and Pathophysiology of AD 120 5.4 Different Stem Cell Application on AD 122 5.5 Challenges and Ethical Considerations 125 5.6 Recent Advancement of Stem Cell Therapy on AD 128 5.7 Clinical Research Updates 130 6 Stem Cell Therapy: A Significant Therapeutic Approach in Wound Healing 141 Richa Dayaramani, Soma Jana, Bratati Bandyopadhyay, Amlan Bishal and Subhashis Debnath 6.1 Introduction 142 6.2 Physiology of Wound-Healing Process 143 6.3 Biology of Stem Cells and their Role in Wound Healing 145 6.4 Stem Cell Therapy for Wound Healing and Histopathological Studies 148 6.5 Stem Cell Delivery Mechanisms for Wound Healing 148 6.6 Clinical Uses of Stem Cell Therapy in Wound Healing 149 6.7 Recent Developments and Technologies in Stem Cell Research for Wound Healing 150 6.8 Challenges in Stem Cell Treatment 151 6.9 Potential Future Applications of Stem Cell-Derived Products in the Use of Stem Cells for Wound Healing 154 6.10 Conclusion 157 7 Stem Cell Therapy: Skin Aging Blocking 163 Dipanjana Ash, Sohini Sen, Sneha Shaw, Ayon Dutta, Leena Kumari and Swarupananda Mukherjee 7.1 Introduction 164 7.2 Stem Cell: An Overview 165 7.3 Mechanisms of SC Action in Skin Regeneration 170 7.4 Preclinical Applications of SC in Skin Aging 173 7.5 Clinical Applications of SC in Skin Aging 175 7.6 Challenges and Considerations 177 7.7 Future Directions and Innovations 181 7.8 Conclusion 182 8 Future Window of Stem Cells in Skin Regeneration and Rejuvenation: Current Status and Future Aspect 195 Vivek Barik, Bramhajit Chatterjee, Snigdha Chatterjee, Swarupananda Mukherjee and Piyali Khamkat 8.1 Introduction 196 8.2 Types of SCs Used in Skin Regeneration and Rejuvenation 198 8.3 Emerging Technologies and Innovations 202 8.4 Challenges in SC-Based Therapies 205 8.5 Future Directions of SCs in Skin Regeneration and Rejuvenation 206 8.6 Current Clinical Trials Updates 208 8.7 Regulatory Challenges for SC-Based Therapies 210 8.8 Conclusion 211 9 Stem Cell Therapy in Dermatology: Challenges and Opportunities 219 Garima Chandak, Sumel Ashique, Shubham Kumar, Narendra Kumar Pandey, Dileep Singh Baghel, Bimlesh Kumar, Saurabh Singh and Omji Porwal 9.1 Introduction 220 9.2 Types of Stem Cells in Dermatology 224 9.3 Mechanisms of Action 225 9.4 Current Applications of Stem Cell Therapy in Dermatology 230 9.5 Advances in Stem Cell Delivery Systems 235 9.6 Challenges in Stem Cell Therapy for Dermatology 238 9.7 Opportunities and Emerging Trends 242 9.8 Preclinical and Clinical Studies 246 9.9 Regulatory and Ethical Considerations 255 9.10 Future Directions 256 9.11 Conclusion 257 10 Clinical Significance and Regulatory Aspects of Stem Cell Therapy 271 Debasmita Paul, Karan Kr. Das, Abhijit Ghosh, Soukat Chandra and Shaileyee Das 10.1 Introduction 272 10.2 Definition and Types of Stem Cells 274 10.3 Mechanisms of Action of Stem Cell Therapy 276 10.4 Future Perspectives 291 10.5 Conclusions and Future Directions 293 11 Translational Research for Dermatological Stem Cell Therapy 301 Mishra Bharti, Khan Anam, Gothalwal Ragini, Jaiswal Prashansa and Kotnis Ashwin 11.1 Introduction 301 11.2 Mechanism of Stem Cell Action in Skin Regeneration and Healing 304 11.3 Current Applications of Stem Cell Therapy in Dermatology 307 11.4 Safety and Challenges in Translating Stem Cell Research to Clinical Practice 310 11.5 Conclusion and Prospects for the Future 312 12 In Vitro and In Vivo Model of Stem Cell Therapy in Dermatological Diseases 321 Sneha Das, Pradip Jana, Mohini Mondal, Mainak Chatterjee and Moitreyee Chattopadhyay 12.1 Introduction 322 12.2 Current and Future Perspectives of SC Therapy in Dermatology by In Vitro and In Vivo Models 325 12.3 In Vitro Models for SC Therapy in Dermatological Diseases 328 12.4 Various Animal Model for In Vivo in Dermatological Diseases 331 12.5 Analytical and Numerical Solutions to the Various Models 334 12.6 Conclusions and Future Directions 335 13 Preclinical and Clinical Trials and Case Studies Involved in Stem Cell Therapy in Dermatological Diseases 341 Rony Mandal, Somali Gorai and Sajal Kumar Jha 13.1 Introduction 342 13.2 Forms of Stem Cell Therapy 343 13.3 Role of Autoimmune System in Dermatological Skin Problem 347 13.4 Therapeutic Value of Stem Cell in Different Allergic Skin Disease 350 13.5 Role of Cutaneous Stem Cells in Regeneration of Different Tissues 352 13.6 Advantages of Stem Cell Therapy for Different Dermatological Diseases 354 13.7 Different In Vivo and In Vitro Models for Preclinical SCT 356 13.8 Preclinical Test Method for Different Skin Disease 360 13.9 FDA-Approved Clinical Phase Trial Drugs for Dermatological Disease 364 13.10 Conclusions and Future Directions 365 References 366 Bibliography 370 Index 371
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