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The efficacy of delavirdine is lower than other FDA approved NNRTIs, therefore, the US department of health and Human Services has recommended its use not as a part of initial therapy but in combination with other drugs. To circumvent this therapeutic difficulty of delavirdine, we amended its structure to develop a novel analogue by replacing its less active indole fragment with a more active anti-HIV prone isatin's Mannich bases. The molecular assemblage of delavirdine was concurrently also altered by rearranging its vital fragments to allow it to emerge with altogether a different molecular setting.