Systemic lupus erythematosus (SLE) with a focus on renal involvement - MUNIMBA KAMBERE, Gerlence
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Systemic lupus erythematosus is a systemic autoimmune disease characterized by the production of autoantibodies directed against constituents of the cell nucleus, leading to chronic multi-organ inflammation. Among visceral disorders, kidney damage - or lupus nephropathy - is one of the most serious complications, occurring in around 50-70% of lupus patients. This condition is often silent at first, but can progress to chronic renal failure if not diagnosed and treated early. The immunological involvement, notably the formation of immune complexes and their deposition in the renal glomeruli,…mehr

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Produktbeschreibung
Systemic lupus erythematosus is a systemic autoimmune disease characterized by the production of autoantibodies directed against constituents of the cell nucleus, leading to chronic multi-organ inflammation. Among visceral disorders, kidney damage - or lupus nephropathy - is one of the most serious complications, occurring in around 50-70% of lupus patients. This condition is often silent at first, but can progress to chronic renal failure if not diagnosed and treated early. The immunological involvement, notably the formation of immune complexes and their deposition in the renal glomeruli, results in variable histological lesions, ranging from benign to severe proliferative forms, as shown by the ISN/RPS classification.The book highlights the diagnostic and therapeutic challenges faced by SLE patients in Africa, particularly in the DRC, and underlines the need for systematic screening of renal function in patients with SLE, using tests such as proteinuria, creatinine clearance and renal biopsy.
Autorenporträt
Dr Gerlence MUNIMBA KAMBERE, born January 26, 1988 in Goma (DRC), is a general practitioner qualified in 2020 and registered with the DRC Medical Association. Involved in both clinical practice and research, he is the author of a book on voluntary interruption of pregnancy published by Congo Mémoire.