David Poyner

The CGRP Family

Calcitonin Gene-Related Peptide (CGRP), Amylin and Adrenomedullin

• Broschiertes Buch

Produktbeschreibung

This book presents a broad overview of Calcitonin, Gene-Related Peptide (CGRP) and the related peptides amylin and adrenomedullin. It deals with the biochemistry, physiology, and pharmacology of receptors for the allied peptides amylin and adrenomedullin.

Produktdetails

• Verlag: CRC Press
• Seitenzahl: 284
• Erscheinungstermin: 2. Dezember 2019
• Englisch
• Abmessung: 229mm x 152mm x 15mm
• Gewicht: 416g
• ISBN-13: 9780367447526
• ISBN-10: 0367447525
• Artikelnr.: 58440938

Autorenporträt

David Poyner

Inhaltsangabe

Section 1: Pharmacology and Molecular Biology of CGRP Receptors 1. Multiple
Receptors for CGRP and Related Peptides 2. CGRP Receptor Heterogeneity: Use
of CGRP8-37 3. Structure Activity Relationship for CGRP 4. The Binding of
CGRP and Adrenomedullin to a Cloned Receptor 5. CGRP Receptors, Structure
and Function 6. Receptor Activity Modifying Proteins(RAMPS) and CRLR Define
the Receptors for CGRP and Adrenomedullin 7. The CGRP-Receptor Component
Protein: A Novel Signal Transduction Protein Section 2: Amylin Receptors 8.
What Makes an Amylin Receptor? 9. Neuroendocrine Actions of Amylin Section
3: Adrenomedullin Receptors 10. Characterization of Adrenomedullin Receptor
Binding in Rat Tissues and Cell Lines 11. Cardiovascular Actions of
Adrenomedullin Section 4: General Pathophysiology of CGRP, Amylin and
Adrenomedullin 12. Calcitonin Gene-Related Peptide in Gastrointestinal
Homeostasis 13. CGRP and Neurogenic Vasodilatation: Role of Nerve Growth
Factor in Diabetes 14. Neurogenically-Derived Pathological Hyperaemia in
Articular Tissues Section 5: CGRP in Migraine and Headache 15. Evidence of
the Involvement of CGRP in Migraine and Cluster Headache: A Physiological
Perspective 16. CGRP, CGRP mRNA and CGRP1 Receptor mRNA and Release from
the Human Trigeminovascular System Section 6: Short Communications 17.
Investigation of Different Pathways for the Relaxant Responses of Human
?CGRP and ?CGRP on Guinea Pig Basilar Artery 18. CGRP Receptors in Rat
Intramural Left Coronary Arteries 19. Discrete Expression of a Putative
CGRP Receptor (RDC1) mRNA in the Rat Brain and Peripheral Tissues 20.
Amylin-Immunoreactivity in Monkey Hypothalamus 21. Analysis o f Responses
to hAmylin and hCGRP in Isolated Resistance Arteries from the Mesenteric
Vascular Bed of the Rat 22. Adrenomedullin in the Rat Placenta and Uterus
23. Effects of ADM and CGRP on Erectile Activity in the Cat 24. Evidence
for a Specific Endothelial Cell Adrenomedullin Receptor Regulating
Endothelin-1 Gene Expression and Synthesis 25. Antimicrobial Effects of
Adrenomedullin and CGRP 26. The Comparative Activity of Adrenomedullin and
CGRP to Potentiate Inflammatory Oedema Formation 27. The Effects of a
Selective CGRP1 Receptor Antagonist, and a Selective Neuronal Nitric Oxide
Synthase Inhibitor on Neurogenic Vasodilatation in the Rat 28. CGRP and NO
in the Regulation of Blood Flow in Rabbit Knee Joints 29. CGRP Modulates
LPS- and Cytokine-Induced iNOS/NO Formation 30. Identification and
Regulation of CGRP in T Lymphocytes of the Rat 31. CGRP and Pregnancy 32.
Characterization of CGRP Receptors in Human Cranial Arteries 33.
CGRP-Mediated Dural Vessel Vasodilation Produces Sensitisation of
Trigeminal Nucleus Caudalis Neurones in Rats 34. Mechanism of CGRP Release
from Sensory Nerve Terminals in Isolated Trachea of the Rat 35. Expression
and Distribution of CGRP Peptide and Receptor in Human Skin