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This Reprint showcases cutting-edge research on chitosan and its derivatives, emphasizing their multifunctional role across biomedical, pharmaceutical, agricultural, and environmental fields. The selected contributions highlight recent progress in drug delivery, wound healing, antimicrobial activity, heavy metal adsorption, and plant protection. Special attention is given to the design of chitosan-based composites, their functionalization, and biocompatibility, as well as their ability to modulate oxidative stress. By bringing together innovative methodologies and practical applications, this Reprint provides a comprehensive and timely overview of how chitosan is being developed into a versatile material to address current scientific and technological challenges.