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In this issue of Hand Clinics, guest editors Drs. Alfred P. Yoon and Kevin C. Chung bring their considerable expertise to the topic of The Essence of Artificial Intelligence in Healthcare. Artificial Intelligence (AI) in healthcare represents a revolutionary shift in how medical professionals approach diagnosis, treatment, and patient care. In this issue, top experts cover new and up-and-coming subfields of artificial intelligence in a digestible manner, as well as their potential applications in medicine. * Contains 11 relevant, practice-oriented topics including AI-enabled remote patient monitoring systems; ethics and policy challenges in applying AI in medicine; natural language processing and large language models; supervised machine learning and clinical decision support; and more * Provides in-depth clinical reviews on the essence of artificial intelligence in healthcare, offering actionable insights for clinical practice * Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews