The Fluoroquinolone Connection. 2nd Edition - Fuzi, Miklos
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Author falling back on findings published by his group and reviewing data reported by other scientists shows how the extensive use of fluoroquinolones influenced the evolution of various multiresistant pathogens on a global scale. It is demonstrated that most bacteria will suffer enormous fitness costs when developing high-level resistance to fluoroquinolones. However, a few "skillful" groups of pathogens proved capable of evolving favorable mutations conferring high-level resistance to fluoroquinolones with the concomitant preservation of vitality. As these multiresistant "superbugs" have…mehr

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Produktbeschreibung
Author falling back on findings published by his group and reviewing data reported by other scientists shows how the extensive use of fluoroquinolones influenced the evolution of various multiresistant pathogens on a global scale. It is demonstrated that most bacteria will suffer enormous fitness costs when developing high-level resistance to fluoroquinolones. However, a few "skillful" groups of pathogens proved capable of evolving favorable mutations conferring high-level resistance to fluoroquinolones with the concomitant preservation of vitality. As these multiresistant "superbugs" have replaced other pathogens in many facilities they also contributed to the deterioration of the general antibiotic resistance status. Though further epidemiological studies are needed the available data strongly suggest that the judicious use of fluoroquinolones could be based on the constant monitoring of the clonal division of local pathogens: if the proportion of "superbugs" is high a reduction in the use of fluoroquinolones should ameliorate the situation, however, when their proportion remains/becomes low the use of fluoroquinolones should be highly beneficial.
Autorenporträt
Miklos Fuzi is a medical doctor and microbiologist working as an associate professor at Semmelweis University, Budapest Hungary. He has been investigating issues related to antibiotic resistance for more than twenty years and has published extensively on the clonal dynamics and antibiotic resistance determinants of various multiresistant pathogens.