"A complete overview of the basal ganglia, including its computational physiology, and its' role in both health and in diseases such as Parkinson's, other movement disorders, and psychiatric diseases"--
"A complete overview of the basal ganglia, including its computational physiology, and its' role in both health and in diseases such as Parkinson's, other movement disorders, and psychiatric diseases"--
Preface xi Acknowledgments xiii I Introduction and Background 1 The Basal Ganglia: Why and Where? 3 2 Cellular Anatomy and Biochemistry of the Basal Ganglia 15 3 The Synaptic Connections of the Basal Ganglia Network 27 4 Computational Modeling of Brain and Behavior 39 5 Principles of Neurophysiological Data Acquisition 43 6 Principles of Neurophysiological Analysis 61 II Computational Physiology of the Healthy Basal Ganglia 7 Physiology of the Basal Ganglia 77 8 Basal Ganglia Physiology: The Roads Less Traveled 89 9 Box-and-Arrow Rate Models of the Basal Ganglia 105 10 Reinforcement-Learning Actor/Critic Models of the Basal Ganglia 117 11 Multiple-Critics, Multiobjective Optimization Models of the Basal Ganglia 133 12 The Basal Ganglia as one of many State-to-Action Loops 145 III Computational Physiology of Basal Ganglia Disorders and their Therapy 13 Parkinson's Disease and other Basal Ganglia-Related Human Disorders 163 14 Animal Models of Parkinson's Disease 171 15 Physiology of Parkinson's Disease: Animal Models 179 16 Physiology of Parkinson's Disease: Human 195 17 Pharmacotherapy of Parkinson's Disease 203 18 Deep Brain Stimulation Therapy for Parkinson's Disease 215 19 Closing the Loop on Parkinson's Disease and Basal Ganglia-Related Disorders 225 IV From the Basal Ganglia and Brain to the Mind 20 The Basal Ganglia, Free Will, and Human Responsibility 241 Notes 247 References 261 Index 295
Preface xi Acknowledgments xiii I Introduction and Background 1 The Basal Ganglia: Why and Where? 3 2 Cellular Anatomy and Biochemistry of the Basal Ganglia 15 3 The Synaptic Connections of the Basal Ganglia Network 27 4 Computational Modeling of Brain and Behavior 39 5 Principles of Neurophysiological Data Acquisition 43 6 Principles of Neurophysiological Analysis 61 II Computational Physiology of the Healthy Basal Ganglia 7 Physiology of the Basal Ganglia 77 8 Basal Ganglia Physiology: The Roads Less Traveled 89 9 Box-and-Arrow Rate Models of the Basal Ganglia 105 10 Reinforcement-Learning Actor/Critic Models of the Basal Ganglia 117 11 Multiple-Critics, Multiobjective Optimization Models of the Basal Ganglia 133 12 The Basal Ganglia as one of many State-to-Action Loops 145 III Computational Physiology of Basal Ganglia Disorders and their Therapy 13 Parkinson's Disease and other Basal Ganglia-Related Human Disorders 163 14 Animal Models of Parkinson's Disease 171 15 Physiology of Parkinson's Disease: Animal Models 179 16 Physiology of Parkinson's Disease: Human 195 17 Pharmacotherapy of Parkinson's Disease 203 18 Deep Brain Stimulation Therapy for Parkinson's Disease 215 19 Closing the Loop on Parkinson's Disease and Basal Ganglia-Related Disorders 225 IV From the Basal Ganglia and Brain to the Mind 20 The Basal Ganglia, Free Will, and Human Responsibility 241 Notes 247 References 261 Index 295
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