The Hypothalamic-Pituitary-Adrenal (HPA) axis in the face of envenomation - Daachi, Fares;Adi-Bessalem, Sonia
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Thehypothalamic-pituitary-adrenal(HPA)axis is a key player in the interaction between the neuroendocrine and immune systems. This study explores the impact ofAndroctonus australis hector(Aah) venom on HPA axis activation, as a function of day-night phases. Using an experimental approach, we analyze the inflammatory responses and oxidative damage induced by envenomation, highlighting the modulation exerted by corticosterone. Increased serum levels of ACTH and corticosterone indicate increased activation of the HPA, most marked during the active phase. At the same time, venom causes oxidative…mehr

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Produktbeschreibung
Thehypothalamic-pituitary-adrenal(HPA)axis is a key player in the interaction between the neuroendocrine and immune systems. This study explores the impact ofAndroctonus australis hector(Aah) venom on HPA axis activation, as a function of day-night phases. Using an experimental approach, we analyze the inflammatory responses and oxidative damage induced by envenomation, highlighting the modulation exerted by corticosterone. Increased serum levels of ACTH and corticosterone indicate increased activation of the HPA, most marked during the active phase. At the same time, venom causes oxidative damage and cardio-hepatic alterations, amplified by excessive production of reactive oxygen and nitrogen species. The involvement of corticosterone in these disturbances was assessed using a dexamethasone suppression test. These results highlight an inflammatory and metabolic response modulated by circadian rhythms, underlining the importance of the HPA in the management of toxic stress.
Autorenporträt
Dr. Daachi Fares, a specialist in biochemistry and immunology, conducts research into the molecular mechanisms of the immune response. A member of the Laboratory of Cellular and Molecular Biology at USTHB, he explores biomolecules and their therapeutic applications, contributing to the development of innovative immunotherapies.