The influence of glycation on neuroblastoma cells - Scheer, Maximilian
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High glucose levels, such as those found in diabetes mellitus, promote the glycation of proteins and lead to the formation of AGEs. These AGEs accelerate aging processes and are associated with micro- and macrovascular complications as well as neurodegenerative diseases. Many effects are receptor-dependent, with RAGE considered one of the most important interaction partners for AGEs. Treatment of Kelly-type neuroblastoma cells with MGO, the most potent precursor of AGE formation, did not result in a reduction in cell viability. After treatment, increased formation of CML and Western blot was…mehr

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Produktbeschreibung
High glucose levels, such as those found in diabetes mellitus, promote the glycation of proteins and lead to the formation of AGEs. These AGEs accelerate aging processes and are associated with micro- and macrovascular complications as well as neurodegenerative diseases. Many effects are receptor-dependent, with RAGE considered one of the most important interaction partners for AGEs. Treatment of Kelly-type neuroblastoma cells with MGO, the most potent precursor of AGE formation, did not result in a reduction in cell viability. After treatment, increased formation of CML and Western blot was observed. Furthermore, glycated cells showed clear signals for CML and RAGE in flow cytometry. Glycation of matrix proteins led to a reduction in adhesion to laminin in RTCA, but had no effect on fibronectin and collagen IV. In addition, an increased migration rate was detected due to glycation of the cells.
Autorenporträt
10/2010-12/2016: Studied human medicine at Martin Luther University Halle-Wittenberg. 11/2013-02/2017: Doctorate at the Institute for Physiological Chemistry, Prof. Horstkorte, Halle. 03/2017-09/2017: Assistant physician in neurology at Martin Gropius Hospital, Eberswalde. Since 09/2017: Assistant physician at the Clinic and Polyclinic for Neurosurgery, Halle.