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The purpose of the present research work was to carryout clinical study on infective vaginal discharge to comparatively examine the coded herbal drug formulation with authentic allopathic medicines. A random controlled clinical trial was conducted to compare the effectiveness and safety of coded herbal medicinal treatments and the screening of antifungal activity Leuko-off and Gynosporin, antibacterial activity Leuko-off and Enoxabid and antiprotozoal activity of Leuko-off and Flagyl were carried out respectively.