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Related the need to search new strategy in vaccine design in order to reduce also some rare -effect like thrombosys for some registered products it is interesting the role played by the SPIKE RGD domain .The binding with molecules like Fibronectin is a process that must to be deeply investigated.A better understanding in this process can be used to improve safety of the new generation of covid vaccine.The rare effect like thrombosis recognized by regulatory- agency produced a modification of technical data sheet of some vaccine so the phenomena Is interesting to be more investigated.