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The sea star IGKappa gene was cloned in 2014 by the use of primers. It was compared in the present work to Vertebrate Immunoglobulin genes. A high identity was found with these last ones. A length of 105 amino-acids fit with Immunoglobulin domain. The sequence of the sea star Asterias rubens IGKappa gene was described by our team, in 2014. Since we have tried to find homologies between this gene and upper genes from lower Vertebrates to human genes. We report, in the precedent paper, results obtained with upper Vertebrate genes by the use of blasts directed against these last ones.