The Vasculome: From Many, One introduces the fundamental bases of the "unity in diversity? of the Vasculome, from the coming together of various cell lineages during development, to its deceptively simple solution for architectural design: the efficient interplay of a few types of building blocks supporting key similar functions throughout the body and their highly specialized functional local variations. Specific examples are included to illustrate how the Vasculome is integral to the function and malfunction of different organs, such as the brain or the kidney. Each section is preceded by an…mehr
The Vasculome: From Many, One introduces the fundamental bases of the "unity in diversity? of the Vasculome, from the coming together of various cell lineages during development, to its deceptively simple solution for architectural design: the efficient interplay of a few types of building blocks supporting key similar functions throughout the body and their highly specialized functional local variations. Specific examples are included to illustrate how the Vasculome is integral to the function and malfunction of different organs, such as the brain or the kidney. Each section is preceded by an introductory summary that will give a high level unified view of the key concepts illustrated in the various chapters in that section. Zorina Galis' The Vasculome was named a finalist in the Clinical Medicine category of the American Association of Publishers' 2023 PROSE Awards.
PART I. THE ARCHITECTURAL DESIGN OF THE VASCULOME: BASIS FOR SYSTEM-WIDE FUNCTIONAL UNITY AND LOCAL DIVERSITY SECTION 1. The Endothelium: Key Unifying Principle of the Vasculome. Basis for Systemic Unity and for Engineering of Local Specialization 1. Developmental of, and environmental impact on, endothelial cell diversity 2. Endothelial cell heterogeneity in health and disease - new insights from single cell studies SECTION 2. Vasculome's Key Building Blocks - Beyond the Endothelium 3. The Remarkable Diversity of Vascular Smooth Muscle in Development and Disease: A paradigm for mesenchymal cell types 4. SMC contractile diversity 5. Resident vascular immune cells in health and atherosclerotic disease 6. Perivascular adipose tissue (physiology, pathology) 7. Major vascular ECM components, differential distribution supporting structure and functions of the Vasculome SECTION 3. Putting it all Together: Integration across Body Scales and within Tissues 8. Out to the Tissues: The Arterial Side (Arteries, Arterioles - Development, Structure, Functions, Pathologies) 9. Capillary diversity: endothelial cell specializations to meet tissue metabolic needs 10. The neurovascular unit and blood-CNS barriers in health and disease 11. Lymphatic biology and medicine PART II. INVESTIGATING THE VASCULOME: CONTEXT-DRIVEN METHODS, USES AND LIMITATIONS SECTION 1. Experimental and Computational Studies of the Vasculome 12. The Flow-dependent Endotheliome: Hemodynamic Forces, Genetic Programs, and Functional Phenotypes 13. Intravital photoacoustic microscopy of microvascular function and oxygen metabolism' 14. Systems biology modeling of endothelial cell and macrophage signaling in angiogenesis in human diseases 15. Simulation of blood flow and oxygen transport in vascular networks 16. Clinical Investigations of vascular function SECTION 2. Realizing the Promise of New High Content Technologies 17. Angiodiversity - A tale retold by comparative transcriptomics 18. Using Pattern Recognition and Discriminant Analysis of Functional Perfusion Data to Create "Angioprints? for Normal and Perturbed Angiogenic Microvascular Networks 19. Artificial Intelligence (AI) for the Vasculome PART III. VASCULOME DYNAMICS: IN HEALTH AND IN SICKNESS SECTION 1. Cooperating during Development and Organogenesis to Create Vasculome Diversity 20. Vascular Development and Organogenesis: Depots of Diversity among Conduits of Connectivity Define the Vasculome 21. Normal Vascular Identity (arteries, veins, lymphatics) and malformations 22. Sprouting Angiogenesis in Vascular and Lymphatic development SECTION 2. Physiological and Pathological Remodeling of the Vasculome 23. Enablers and drivers of vascular remodeling 24. Extracellular Matrix Dynamics and Contribution to Vascular Pathologies 25. Lymphatic vasculature anomalies and dysfunction PART IV. THE VASCULOME AS PERPETRATOR AND VICTIM IN LOCAL AND SYSTEMIC DISEASES 26. Endothelial dysfunction: basis for many local and systemic conditions 27. The vascular phenotype in hypertension 28. Functional roles of lymphatics in health and disease 29. Extracellular Matrix Genetics of Thoracic and Abdominal Aortic Diseases 30. Peripheral arterial disease (pathophysiology, presentation, prevention/management) 31. Venous Diseases Including Thromboembolic Phenomena PART V. THE VASCULOME IN DIAGNOSIS, PREVENTION, AND TREATMENT OF OTHER DISEASES 32. Targeting vascular zip codes: from combinatorial selection to drug prototypes 33. Angiosome concept for vascular interventions 34. RNA therapies for cardiovascular disease 35. The Brain Vasculome: An Integrative Model for CNS Function and Disease PART VI. Looking Forward Toward "Precision Health" for the Vasculome 36. Defining and Optimizing Vascular health 37. The Vasculome provides a Body-wide Cellular Positioning System and Functional Barometer. The "Vasculature as Common Coordinate Frame (CCF)? Concept
PART I. THE ARCHITECTURAL DESIGN OF THE VASCULOME: BASIS FOR SYSTEM-WIDE FUNCTIONAL UNITY AND LOCAL DIVERSITY SECTION 1. The Endothelium: Key Unifying Principle of the Vasculome. Basis for Systemic Unity and for Engineering of Local Specialization 1. Developmental of, and environmental impact on, endothelial cell diversity 2. Endothelial cell heterogeneity in health and disease - new insights from single cell studies SECTION 2. Vasculome's Key Building Blocks - Beyond the Endothelium 3. The Remarkable Diversity of Vascular Smooth Muscle in Development and Disease: A paradigm for mesenchymal cell types 4. SMC contractile diversity 5. Resident vascular immune cells in health and atherosclerotic disease 6. Perivascular adipose tissue (physiology, pathology) 7. Major vascular ECM components, differential distribution supporting structure and functions of the Vasculome SECTION 3. Putting it all Together: Integration across Body Scales and within Tissues 8. Out to the Tissues: The Arterial Side (Arteries, Arterioles - Development, Structure, Functions, Pathologies) 9. Capillary diversity: endothelial cell specializations to meet tissue metabolic needs 10. The neurovascular unit and blood-CNS barriers in health and disease 11. Lymphatic biology and medicine PART II. INVESTIGATING THE VASCULOME: CONTEXT-DRIVEN METHODS, USES AND LIMITATIONS SECTION 1. Experimental and Computational Studies of the Vasculome 12. The Flow-dependent Endotheliome: Hemodynamic Forces, Genetic Programs, and Functional Phenotypes 13. Intravital photoacoustic microscopy of microvascular function and oxygen metabolism' 14. Systems biology modeling of endothelial cell and macrophage signaling in angiogenesis in human diseases 15. Simulation of blood flow and oxygen transport in vascular networks 16. Clinical Investigations of vascular function SECTION 2. Realizing the Promise of New High Content Technologies 17. Angiodiversity - A tale retold by comparative transcriptomics 18. Using Pattern Recognition and Discriminant Analysis of Functional Perfusion Data to Create "Angioprints? for Normal and Perturbed Angiogenic Microvascular Networks 19. Artificial Intelligence (AI) for the Vasculome PART III. VASCULOME DYNAMICS: IN HEALTH AND IN SICKNESS SECTION 1. Cooperating during Development and Organogenesis to Create Vasculome Diversity 20. Vascular Development and Organogenesis: Depots of Diversity among Conduits of Connectivity Define the Vasculome 21. Normal Vascular Identity (arteries, veins, lymphatics) and malformations 22. Sprouting Angiogenesis in Vascular and Lymphatic development SECTION 2. Physiological and Pathological Remodeling of the Vasculome 23. Enablers and drivers of vascular remodeling 24. Extracellular Matrix Dynamics and Contribution to Vascular Pathologies 25. Lymphatic vasculature anomalies and dysfunction PART IV. THE VASCULOME AS PERPETRATOR AND VICTIM IN LOCAL AND SYSTEMIC DISEASES 26. Endothelial dysfunction: basis for many local and systemic conditions 27. The vascular phenotype in hypertension 28. Functional roles of lymphatics in health and disease 29. Extracellular Matrix Genetics of Thoracic and Abdominal Aortic Diseases 30. Peripheral arterial disease (pathophysiology, presentation, prevention/management) 31. Venous Diseases Including Thromboembolic Phenomena PART V. THE VASCULOME IN DIAGNOSIS, PREVENTION, AND TREATMENT OF OTHER DISEASES 32. Targeting vascular zip codes: from combinatorial selection to drug prototypes 33. Angiosome concept for vascular interventions 34. RNA therapies for cardiovascular disease 35. The Brain Vasculome: An Integrative Model for CNS Function and Disease PART VI. Looking Forward Toward "Precision Health" for the Vasculome 36. Defining and Optimizing Vascular health 37. The Vasculome provides a Body-wide Cellular Positioning System and Functional Barometer. The "Vasculature as Common Coordinate Frame (CCF)? Concept
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