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Thiadiazines are six-membered heterocyclic compounds with two nitrogens and one sulphur atom. Diverse biological effects are associated with thiadiazines bearing hetero atoms at 1,2,4 or 1,3,4 positions. The work has been a continuation of our work from the series of eight books as Pyrimidines, Quinazolines, Pyrimidines fused with heterocyclic rings, Novel Pyrazoles part I, Novel Pyrazoles part II and Triazolo Pyrimidines, Thiazolo pyrimidines and Triazolo Quinazolines. The present book entitled "Thiadiazines: synthesis and biological prediction study" includes a brief survey of the literature taken for medicinal significance and Synthetic Approaches and Applications of thiadiazines and the Synthesis, Characterization and Biological Prediction Study of thiadiazin-2-yl-thiazolidin-4-one derivatives.