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Many peptides by their cell molecular metabolism in the thyroid gland are involved : mutations of TSH receptor is linked to hormone resistance with congenital hypothyroidism. ; a new oroxigenic peptide, Ghrelin is widespread in endocrine tissues ; tachykinine is another novel peptide with endocrine paracrine effect. PTTG and FGF-2 are prognostic markers of differentiated cancers ; CRIF1 is a novel protein of nucleus interacting with Gadd45 and could negatively regulate cycle cell progression and cell growth ; mutations of RET protooncogene is now the best CMT biomarker in the place of calcitonin in addition with CGRP, CGRPß and Amylin ; regulating proteins of CAMP, protein G, Gi alpha 1, MAL proteolipid are identified near immunologic antigens involved in Grave's disease, autoimmune polyendocrinopathies.These peptides by their diversity of function support the concept of general endocrinology equivalent of medical sciences.