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LEFT AND RIGTH Colon cancer can be considered a really interesting model to better understand what happen in a single apparatus and the related cancer phenomena Environmental risk factors, hereditary syndromes and "sporadic" form added to 2 final different kind of pathology ( LEFT and right CANCER ) contribute to a real complex epidemiological situation. Aim of this work is to set 2 different kinds of "TOXIC-PATHOLOGIC " factors that make possible whit their GRADIENT the development of this 2 different kind of cancer in the same part of an apparatus.