Inspired by the need to offer a relevant approach to interrogations suited to contemporary times with its ever-increasing demands for transparency and calls for fundamental respect of human rights and human dignity, this primer serves as a timely and handy reference for those working or thinking of working as an interrogator in law enforcement, the military, or intelligence. Challenging past beliefs and practices, it provides evidence-based insights and best practices to improve interrogation results while laying out novel approaches that no longer rely on physical and psychological coercion, deceptive ruses, or abuse.