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Natural products have a wide range of diversity of multidimensional chemical structures which play a vital role which show the important nature as golden source for achieving the herbal drug discovery. Natural products have played a key role in drug discovery and development in modern days. Thymoquinone has a wide a range of beneficial pharmacological properties including antioxidant, anticancer, anti-inflammatory, hypoglycemic, neuro-, cardio-, nephro- and hepatoprotective with tremendous immune-modulating property.