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The delivery of drugs into systemic circulation via skin has generated lot of interest in recent time. Transdermal drug delivery is now a promising route of drug delivery system. The transdermal drug delivery system has potential advantages of avoiding hepatic first pass metabolism, maintaining constant blood levels for longer period of time, decrease side effects, decrease gastrointestinal effect that occur due to local contact with gastric mucosa and improved compliance. The success of transdermal drug delivery system depends on the ability of the drug to penetrate through the skin in sufficient quantities to achieve desired therapeutic levels. Matrix systems is one of the method to delivery drug directly to blood circulation. Iontophoresis is one of the physical approach in enhancement of transdermal permeation. This utilizes electric current as a driving force for permeation of ionic and nonionic medications.