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Chronic post-viral hepatitis C is a major public health problem, with around 71 million people infected worldwide. Until 2011, treatment was based on pegylated dual therapy, with a sustained virological response (SVR) rate of between 40% and 80%, depending on the genotype, albeit with a number of contraindications and adverse effects limiting its prescription. The advent of new direct antiviral agents (DAAs) has brought about a metamorphosis in the management of chronic post-viral hepatitis C, with SVR reaching 90-100% and few adverse effects. The aim of our work was to evaluate the efficacy and safety of direct antiviral agents in a cohort of patients with chronic post-viral hepatitis C. This was a descriptive, cross-sectional, prospective study including all patients followed for chronic post-viral hepatitis C in the Nabeul hepato gastroenterology department, and who were included in the national hepatitis C virus eradication program.