Keith Alan Foster / Peter Hambleton / Cliff Shone (eds.)

Treatments from Toxins

The Therapeutic Potential of Clostridial Neurotoxins
Herausgeber: Foster, Keith Alan; Shone, Clifford C.; Hambleton, Peter

• Gebundenes Buch

Produktbeschreibung

The recent, rapid developments in the scientific understanding of the structure and function of clostridial toxins have opened the door to therapeutic uses of and treatments against these potent neurotoxins. They have found applications in treating focal dystonias, spastic paralysis in children with cerebral palsey, pain relief, and as targeted drug delivery agents for the nervous system. . Many clinicians, however, are using preparations without awareness of available information that could improve and expand their use. This book integrates the most recent scientific and clinical information from top international authorities covering the structure, mechanisms of action with current and emerging applications of these toxins.

Produktdetails

• Verlag: CRC Press
• Seitenzahl: 316
• Erscheinungstermin: 2. November 2006
• Englisch
• Abmessung: 240mm x 161mm x 22mm
• Gewicht: 640g
• ISBN-13: 9780849327094
• ISBN-10: 0849327091
• Artikelnr.: 21187896

Autorenporträt

Keith Alan Foster, Peter Hambleton, Clifford C. Shone

Inhaltsangabe

Introduction and Historical Perspective. Three-Dimensional Protein
Structures of Light Chains of Botulinum Neurotoxin Serotypes A, B, and E
and Tetanus Neurotoxin. Mechanisms of Actions of Neurotoxins. Vaccines to
Protect against Neurotoxins. Inhibitors of Clostridial Neurotoxin
Proteinase Activities. Introduction to Clinical Use of Botulinum
Neurotoxins. Expanding Clinical Uses of Botulinum Neurotoxins. Development
of Therapeutics Based upon Clostridial Endopeptidase Activity. Use of
Neurotoxins as Drug Delivery Systems. Conclusions and Future Perspectives:
Botulinum Neurotoxins as Paradigms for Development of Microbial
Effector-Derived Drugs. Index.