Tumor Necrosis Factors
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High Quality Content by WIKIPEDIA articles! Tumor necrosis factors (or the TNF-family) refers to a group of cytokines family that can cause cell death. At the end of 19th century William Coley, a New York surgeon, described remission of tumors following bacterial infection. In 1975 a protein responsible for this process was identified and called tumor necrosis factor alpha (TNF-alpha). An article on the history of fever therapy, as it was called, and TNF up to 1991, with references to clinical and double-blind studies but under the heading of complementary and alternative therapies, has been…mehr

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High Quality Content by WIKIPEDIA articles! Tumor necrosis factors (or the TNF-family) refers to a group of cytokines family that can cause cell death. At the end of 19th century William Coley, a New York surgeon, described remission of tumors following bacterial infection. In 1975 a protein responsible for this process was identified and called tumor necrosis factor alpha (TNF-alpha). An article on the history of fever therapy, as it was called, and TNF up to 1991, with references to clinical and double-blind studies but under the heading of complementary and alternative therapies, has been published. TNF acts via the TNF Receptor (TNF-R) and is part of the extrinsic pathway for triggering apoptosis. TNF-R is associated with procaspases through adapter proteins (FADD, TRADD, etc.) that can cleave other inactive procaspases and trigger the caspase cascade, irreversibly committing the cell to apoptosis.