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The rational scientific approach to face a potentially fatal viral pandemic with no known effective specific therapies dictate the early use of all the useful preliminary research evidence with prioritizing emphasis on safety to avoid making more harm than good in such situation. We have previously published an evidence-based keys to the therapeutic challenge associated with the emergence of SARS-CoV-2 pandemic. The aim of this paper is to provide and important updates to keys to the therapeutic challenge which are hoped to help in cracking the padlock of SARS-CoV-2.