G. Hermann Jonas TAPSOBA

Virulence of Candida tropicalis : Experimental study

Study of the virulence of a telluric strain of Candida tropicalis using the Galleria mellonella model

• Broschiertes Buch

Produktbeschreibung

Candida tropicalis is one of the most feared non-albicans C. species in the world (3 to 66% of isolates). The aim of the study was to assess the in vivo virulence of a telluric strain of C. tropicalis based on the G. mellonella model. The study was carried out in Burkina Faso.It was a prospective experimental study. Batches of 10 larvae of 280 to 320mg and a telluric strain of C. tropicalis identified by MALDI-TOF were used. Larvae were inoculated with 20mil of fungal suspension at increasing concentrations of 5,105, 1,106, and 5,106 CFU. A control group was injected with 20miL of sterile PBS. Melanisation and larval death were observed at 24 h over 12 days.In total, 100% of the larvae melanised 30 min after inoculation at concentrations of 1,106 and 5,106 CFU/larva and mortality was 100% at H48 (p<0.001). There was no change in the control group.C. tropicalis causes serious infections. This experimental model could be taken as the gold standard for experiments on the virulence of fungal microorganisms.

Produktdetails

• Verlag: Our Knowledge Publishing
• Seitenzahl: 52
• Erscheinungstermin: 10. Februar 2025
• Englisch
• Abmessung: 220mm x 150mm x 4mm
• Gewicht: 96g
• ISBN-13: 9786208624637
• ISBN-10: 6208624630
• Artikelnr.: 73322710

Autorenporträt

2024: Tese de mestrado em Parasitologia-Micologia Médica, Universidade Joseph Ki Zerbo (UJKZ), Ouagadougou2021: Diplôme d'Etude Spécialisées (DES) em Biologia Clínica, UJKZ2013: Doutoramento em Medicina, UJKZ.2004: BAC série D (científico), Bobo Dioulasso.