Water-Insoluble Drug Formulation, Third Edition serves as a comprehensive reference for pharmaceutical scientists in the handling of formulation issues related to water-insoluble drugs.
Water-Insoluble Drug Formulation, Third Edition serves as a comprehensive reference for pharmaceutical scientists in the handling of formulation issues related to water-insoluble drugs.
Ron Liu is CEO of AustarPharma, a pharmaceutical company based in Edison, New Jersey.
Inhaltsangabe
Introduction. Solubility Theory. Prediction of Solubility. Preformulation Aspects of Insoluble Compounds. Water-Insoluble Drugs and Their Pharmacokinetic Behaviors. Regulatory Aspects of Dissolution for Low Solubility Drug Products. Formulation Strategies and Practice Used for Drug Candidates with Water-Insoluble Properties for Toxicology, Biology, and Pharmacology Studies in Discovery Support. Application of Complexation in Drug Development for Insoluble Compounds. Solubilization Using Cosolvent Approach. Emulsions, Microemulsions, and Lipid-Based Drug Delivery Systems for Drug Solubilization and Delivery Part I: Parenteral Applications. Emulsions, Microemulsions, and Lipid-Based Drug Delivery Systems for Drug Solubilization and Delivery Part II: Oral Applications. Micellization and Drug Solubility Enhancement. Polymeric Micelles in Water-Insoluble Drug Delivery. Liposomes in Solubilization. Pharmaceutical Salts. Prodrugs for Improved Solubility in Water. Particle Size Reduction. Development of Solid Dispersion for Poorly Water-Soluble Drugs. Alteration of the Solid State of the Drug Substances: Polymorphs, Solvates, and Amorphous Forms. Pharmaceutical Powder Technology ICH Q8 and Building the Pyramid of Knowledge. Soft Gelatin Capsules Development. Oral Modified-Release Drug Delivery for Water-Insoluble Drugs. Scalable Manufacturing of Water-Insoluble Drug Products. Index.
Introduction. Solubility Theory. Prediction of Solubility. Preformulation Aspects of Insoluble Compounds. Water-Insoluble Drugs and Their Pharmacokinetic Behaviors. Regulatory Aspects of Dissolution for Low Solubility Drug Products. Formulation Strategies and Practice Used for Drug Candidates with Water-Insoluble Properties for Toxicology, Biology, and Pharmacology Studies in Discovery Support. Application of Complexation in Drug Development for Insoluble Compounds. Solubilization Using Cosolvent Approach. Emulsions, Microemulsions, and Lipid-Based Drug Delivery Systems for Drug Solubilization and Delivery Part I: Parenteral Applications. Emulsions, Microemulsions, and Lipid-Based Drug Delivery Systems for Drug Solubilization and Delivery Part II: Oral Applications. Micellization and Drug Solubility Enhancement. Polymeric Micelles in Water-Insoluble Drug Delivery. Liposomes in Solubilization. Pharmaceutical Salts. Prodrugs for Improved Solubility in Water. Particle Size Reduction. Development of Solid Dispersion for Poorly Water-Soluble Drugs. Alteration of the Solid State of the Drug Substances: Polymorphs, Solvates, and Amorphous Forms. Pharmaceutical Powder Technology ICH Q8 and Building the Pyramid of Knowledge. Soft Gelatin Capsules Development. Oral Modified-Release Drug Delivery for Water-Insoluble Drugs. Scalable Manufacturing of Water-Insoluble Drug Products. Index.
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