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This book reports on cutting-edge research and best practices in the broad field of biomedical engineering. Based on the XLVIII Mexican Conference on Biomedical Engineering, CNIB 2025, held on September 11-13, 2025, in Monterrey, Nuevo León, México, this first volume of the proceedings covers research topics in biomedical signal processing and brain-computer interfaces, and applications of artificial intelligence and data science in biomedicine, alike. All in all, this book provides a timely snapshot on state-of-the-art achievements in biomedical engineering and current challenges in the field. It addresses both researchers and professionals, and it is expected to foster future collaborations between the two groups, as well as international collaborations.