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I have seen dozens of generations of medical residents pass through; and during that journey I had the opportunity to direct a 200 thesis. I realized that for many, facing the task of designing a research project often seems like an uncertain path: where do I start, what methodology should I choose, how do I turn an idea into a solid thesis?This booklet is not intended to be an exhaustive treatise on methodology, but rather a clear, practical and well-founded guide that will allow you to advance confidently through each step. Here you will find an explanation of the main clinical research designs, their advantages and limitations, but also real examples, diagrams and comparisons that will facilitate your understanding. My intention is to help you understand the theory of clinical research, but also to help you learn how to apply it in your hospital context, which will benefit your patients and allow you to better interpret the medical literature in the light of your medical practice.