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  • Format: ePub

Acromegaly is a rare disease which is caused when the pituitary gland produces too much growth hormone.
Normally a benign (non cancerous) tumor of the pituitary gland results in the gland producing too much growth hormone.
Too much growth hormone in children produces gigantism rather than acromegaly.
Symptoms of acromegaly are:
1. Reduced muscle strength (weakness)
2. Reduced peripheral vision
3. Easy fatigue
4. Increased height
5. Large bones of the face
6. Large feet (change in shoe size), large hands (change in ring or glove size)
7. Large glands in the skin
…mehr

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Produktbeschreibung
Acromegaly is a rare disease which is caused when the pituitary gland produces too much growth hormone.
Normally a benign (non cancerous) tumor of the pituitary gland results in the gland producing too much growth hormone.
Too much growth hormone in children produces gigantism rather than acromegaly.
Symptoms of acromegaly are:
1. Reduced muscle strength (weakness)
2. Reduced peripheral vision
3. Easy fatigue
4. Increased height
5. Large bones of the face
6. Large feet (change in shoe size), large hands (change in ring or glove size)
7. Large glands in the skin (sebaceous glands)
8. Large jaw (prognathism) and tongue (macroglossia)
There are other symptoms that may occur with this condition:
1. Colon polyps
2. Increased hair growth in females (hirsutism)
3. Type 2 diabetes
4. Enlarged thyroid
To confirm diagnosis of acromegaly the following tests may be done:
1. Growth hormone
2. Blood glucose
3. High insulin-like growth factor 1 (IGF-1) level
4. Spine x-ray
5. MRI of the brain, including the pituitary gland
Treatment
1. Surgery for removal of the pituitary tumor that is causing this condition often treats the release of abnormal growth hormone.
Sometimes the tumor is too big to remove totally.
2. People who are not responsive to surgery may have radiation of the pituitary gland.
3. Tests of pegvisomant (Somavert), a GH-receptor antagonist, showed effective suppression of GH and IGF-I levels in patients with acromegaly due to pituitary tumors or ectopic GHRH hypersecretion.
Normalization of IGF-I levels occurs in as many as 90% of patients treated daily with this drug for 3 months.
4. Bromocriptine (Parlodel, Cycloset)
This is the dopamine-receptor agonist that is most often used to treat GH and prolactin excess.
It is safe when administered to a child for extended period.

In acromegaly, a severe disease that is often diagnosed late, morbidity and mortality rates are high, particularly as a result of associated cardiovascular, cerebrovascular, and respiratory disorders and malignancies.
Because IGF-I is a general growth factor, somatic hypertrophy in acromegaly occurs across all organ systems.
Associated complications include the following:
1. Acromegalic heart
2. Increased muscle and soft tissue mass
3. Increased kidney size
4. Articular overgrowth of synovial tissue and hypertrophic arthropathy
5. Joint symptoms, back pain, and kyphosis

TABLE OF CONTENT
Introduction
Chapter 1 Acromegaly
Chapter 2 Causes
Chapter 3 Symptoms
Chapter 4 Diagnosis
Chapter 5 Treatment
Chapter 6 Prognosis
Chapter 7 Dwarfism or Growth Hormone Deficiency
Epilogue


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Autorenporträt
Dr. Kenneth Kee is a well-known medical doctor from Singapore who has been practicing medicine since 1972.
He graduated from the University of Singapore and furthered his studies with a Master of Science in Health Management in 1991, followed by a Ph.D. in Healthcare Administration in 1993.
Dr. Kee established Kee Clinic in 1974, located in the Holland Drive area of Singapore. The clinic has been a prominent feature of the community, offering general medical services for 5 decades.
Dr Kee also served his country Singapore as a national service police Inspector at night from 1975 to 1985 while working at his clinic during the day.
He had served as a police guard to the Woodland Petroleum Tanks at night during the Indonesian Confrontation period, took part in police rounds at night in the Beach Road area and taught First aid and emergency resuscitation to Police recruits.
He received the Singapore Police Bicentennial 2020 Medallion on 1st March 2024 as recognition for his work in the Singapore Police.
Even as he grew older, Dr. Kee continued to work actively in his clinic, although he eventually reduced his consultation hours.
Beyond his medical career, Dr. Kee is also an author.
He started writing about medical conditions in 2007, using blogs and other online platforms to share his knowledge with a broader audience.
Over time, he published various books, many of which provide simple and accessible guides to different health conditions.
His works include "A Family Doctor's Tale," "My Personal Singapore History," and numerous medical guides, available through platforms like Amazon.
His books often combine his personal experiences as a family doctor with insights into Singapore's healthcare system and history.
Dr. Kee has written extensively on health topics, contributing to both medical literature and general knowledge resources.

Dr. Kenneth Kee has written numerous books, primarily focused on health education and personal experiences as a family doctor. Some of his notable titles include:
"A Family Doctor's Tale"
This book is a blend of Dr. Kee's personal experiences and his reflections on being a family doctor in Singapore. It's a great choice if you're looking for a narrative that combines both medical knowledge and human stories.
"Specialized Medical Conditions"
Books like **"Congestive Heart Failure: Diagnosis and Treatment"** focus on specific conditions, offering in-dept...